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Effects of cyclohexanone analogues of curcumin on growth, apoptosis and NF-κB activity in PC-3 human prostate cancer cells.姜黄素环己酮类似物对PC-3人前列腺癌细胞生长、凋亡及核因子κB活性的影响
Oncol Lett. 2012 Aug;4(2):279-284. doi: 10.3892/ol.2012.710. Epub 2012 May 10.
2
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Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.姜黄素通过抑制IκBα磷酸化来抑制核因子-κB，从而使前列腺癌细胞对肿瘤坏死因子相关凋亡诱导配体/Apo2L敏感。
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Effects of curcumin analogues for inhibiting human prostate cancer cells and the growth of human PC-3 prostate xenografts in immunodeficient mice.姜黄素类似物对抑制人前列腺癌细胞及免疫缺陷小鼠体内人PC-3前列腺异种移植瘤生长的作用。
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Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells.α-番茄碱与姜黄素联合抑制人前列腺癌细胞生长并诱导其凋亡。
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L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis.异位表达RelA的L-929细胞对姜黄素诱导的凋亡具有抗性。
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Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway.姜黄素[1,7 - 双(4 - 羟基 - 3 - 甲氧基苯基)-1,6 - 庚二烯 - 3,5 - 二酮；C21H20O6]通过抑制促生存的Akt信号通路来抑制核因子 - κB，从而使人前列腺癌细胞对肿瘤坏死因子相关凋亡诱导配体/Apo2L诱导的凋亡敏感。
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Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells.姜黄素可预防人自分泌生长激素（GH）信号介导的NF-κB激活，以及miR-183-96-182簇刺激的T47D乳腺癌细胞上皮-间质转化。
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Synthesis, characterization, quantum mechanical calculations and biomedical docking studies on curcumin analogs: 2, 6-(Difurfurylidene) cyclohexanone and 2, 6 - Bis (2,6-Dichloro Benzylidene) Cyclohexanone.姜黄素类似物：2,6 -（二糠叉基）环己酮和2,6 - 双（2,6 - 二氯亚苄基）环己酮的合成、表征、量子力学计算及生物医学对接研究
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Nanoscale Formulations: Incorporating Curcumin into Combination Strategies for the Treatment of Lung Cancer.纳米制剂：将姜黄素纳入联合策略治疗肺癌。
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Celecoxib combined with salirasib strongly inhibits pancreatic cancer cells in 2D and 3D cultures.塞来昔布联合沙利昔布在 2D 和 3D 培养物中强烈抑制胰腺癌细胞。
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The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies.姜黄素在前列腺癌中的潜在作用：临床研究中优化药代动力学的重要性。
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Cyclohexanone curcumin analogs inhibit the progression of castration-resistant prostate cancer in vitro and in vivo.环己酮姜黄素类似物在体外和体内抑制去势抵抗性前列腺癌的进展。
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Robust volcano plot: identification of differential metabolites in the presence of outliers.稳健火山图：在存在离群值的情况下鉴定差异代谢物。
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本文引用的文献

1
Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IκB kinase complex signaling axis in adenoid cystic carcinoma.姜黄素通过交叉的磷脂酰肌醇 3-激酶/ Akt/IκB 激酶复合物信号轴双重抑制哺乳动物雷帕霉素靶蛋白和核因子-κB 通路在腺样囊性癌中。
Mol Pharmacol. 2011 Jan;79(1):106-18. doi: 10.1124/mol.110.066910. Epub 2010 Oct 19.
2
Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin.姜黄素杂环环己酮类似物的合成及细胞毒性研究。
Bioorg Med Chem. 2010 Sep 15;18(18):6701-7. doi: 10.1016/j.bmc.2010.07.063. Epub 2010 Aug 1.
3
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.RelB 调节前列腺癌细胞的锰超氧化物歧化酶基因和对电离辐射的抗性。
Ann N Y Acad Sci. 2010 Jul;1201:129-36. doi: 10.1111/j.1749-6632.2010.05613.x.
4
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.姜黄素通过抑制 NFkappaB 和胰腺癌细胞及肿瘤生长取决于特异性蛋白下调。
J Biol Chem. 2010 Aug 13;285(33):25332-44. doi: 10.1074/jbc.M109.095240. Epub 2010 Jun 9.
5
Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen.大豆异黄酮和姜黄素联合抑制前列腺特异性抗原的产生。
Prostate. 2010 Jul 1;70(10):1127-33. doi: 10.1002/pros.21147.
6
Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria.姜黄素诱导 PC3 前列腺癌细胞凋亡不依赖于半胱天冬酶，并涉及细胞神经酰胺积累和线粒体损伤。
Nutr Cancer. 2010;62(3):379-89. doi: 10.1080/01635580903441238.
7
Possible benefits of curcumin regimen in combination with taxane chemotherapy for hormone-refractory prostate cancer treatment.姜黄素方案联合紫杉烷类化疗治疗激素难治性前列腺癌的可能获益。
Nutr Cancer. 2010;62(2):148-53. doi: 10.1080/01635580903305383.
8
Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2.对干扰素-α诱导凋亡的抵抗与 STAT2 的丧失有关。
Mol Cancer Res. 2010 Jan;8(1):80-92. doi: 10.1158/1541-7786.MCR-08-0344. Epub 2010 Jan 12.
9
NF-kappaB as a critical link between inflammation and cancer.NF-κB 作为炎症和癌症之间的关键联系。
Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141. doi: 10.1101/cshperspect.a000141.
10
Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines.杂环环己酮姜黄素衍生物在雌激素受体阴性人乳腺癌细胞系中的活性机制。
Invest New Drugs. 2011 Feb;29(1):87-97. doi: 10.1007/s10637-009-9339-0. Epub 2009 Oct 9.

姜黄素环己酮类似物对PC-3人前列腺癌细胞生长、凋亡及核因子κB活性的影响

Effects of cyclohexanone analogues of curcumin on growth, apoptosis and NF-κB activity in PC-3 human prostate cancer cells.

作者信息

Wei Xingchuan, DU Zhi-Yun, Cui Xiao-Xing, Verano Michael, Mo Rong Qing, Tang Zhi Kai, Conney Allan H, Zheng Xi, Zhang Kun

机构信息

Department of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, P.R. China.

出版信息

Oncol Lett. 2012 Aug;4(2):279-284. doi: 10.3892/ol.2012.710. Epub 2012 May 10.

DOI:10.3892/ol.2012.710
PMID:22844370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3402731/
Abstract

Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A(1)-A(6)) were investigated for their effects on growth and apoptosis in PC-3 human prostate cancer cells. The ability of these compounds to inhibit NF-κB activity in PC-3 cells was also determined. Five out of the six curcumin analogues (A(2)-A(6)) had stronger inhibitory effects compared to curcumin on the growth of cultured PC-3 cells. Compounds A(2)-A(6) also had stronger stimulatory effects on apoptosis in PC-3 cells than curcumin, and these curcumin analogues more potently inhibited NF-κB activity than curcumin. The inhibitory effects of these compounds on NF-κB activity correlated with their effects on growth inhibition and apoptosis stimulation in PC-3 cells. The results of the present study provide a rationale for in vivo studies with A(2)-A(6) using suitable animal models of prostate cancer.

摘要

姜黄素是一种存在于姜黄香料中的非营养性黄色色素，姜黄源自植物姜黄（Curcuma longa Linn）的根茎。研究了姜黄素的六种环己酮类似物（A(1)-A(6)）对PC-3人前列腺癌细胞生长和凋亡的影响。还测定了这些化合物抑制PC-3细胞中NF-κB活性的能力。六种姜黄素类似物中的五种（A(2)-A(6)）对培养的PC-3细胞生长的抑制作用比姜黄素更强。化合物A(2)-A(6)对PC-3细胞凋亡的刺激作用也比姜黄素更强，并且这些姜黄素类似物比姜黄素更有效地抑制NF-κB活性。这些化合物对NF-κB活性的抑制作用与其对PC-3细胞生长抑制和凋亡刺激的作用相关。本研究结果为使用合适的前列腺癌动物模型对A(2)-A(6)进行体内研究提供了理论依据。