Masaki Takayuki
Department of Internal Medicine 1, Faculty of Medicine, Oita University.
Nihon Rinsho. 2012 Jul;70(7):1183-7.
It is increasingly recognized that obesity is an important health problem. The mechanisms that underlie obesity have not been fully elucidated, and effective therapeutic approaches are currently of general interest. Recent studies have provided evidence that circadian clock is a crucial factor in the development of obesity and related metabolic disease. Genetic disruption of clock genes in mice displayed metabolic dysfunctions of specific tissues at distinct phases of the sleep/wake cycle. In addition, circadian desynchrony, a characteristic of shift work and short sleep, are associated with obesity in human. Here, I describe the advances in understanding the interrelationship among circadian disruption, sleep deprivation and obesity.
人们越来越认识到肥胖是一个重要的健康问题。肥胖背后的机制尚未完全阐明，目前有效的治疗方法备受关注。最近的研究提供了证据表明生物钟是肥胖及相关代谢疾病发展的关键因素。小鼠生物钟基因的遗传破坏在睡眠/觉醒周期的不同阶段表现出特定组织的代谢功能障碍。此外，昼夜节律失调，即轮班工作和睡眠不足的特征，与人类肥胖有关。在此，我描述了在理解昼夜节律紊乱、睡眠剥夺和肥胖之间相互关系方面的进展。
