Beck Ruy C R, Ourique Aline F, Guterres Silvia S, Pohlmann Adriana R
Programa de Pós-Graduação em Nanotecnologia Farmacêutica, Universidade Federal do Rio Grande do Sul, Av. Ipiranga2752, Porto Alegre, 90610-000, RS, Brazil.
Recent Pat Drug Deliv Formul. 2012 Dec;6(3):195-208. doi: 10.2174/187221112802652651.
Polymeric nanoparticles have been the focus of several researches in the last three decades in diverse areas including the delivery of pharmaceutical, diagnostic and cosmetic agents. These nanocarriers are able to improve the bioavailability and intrinsic solubility of drugs, to target different agents to a specific location or to protect the agent against extrinsic factors, such as radiation and extreme pH conditions. Despite the high interest in the development of these formulations, they hold some disadvantages like the limited physicochemical stability, which hinders the scaling-up of the preparation methods. In this context, spray-drying techniques have been proposed to obtain powder compositions containing polymeric nanoparticles allowing this limited property to be circumvented. In this context, this review is focused on the latest patents related to obtaining spray-dried polymeric nanoparticles, which have been divided into three different groups, according to their approach: i) spray-drying solutions to obtain nanoparticles, ii) spray-drying emulsions/ dispersions to obtain nanoparticles, and iii) nanoparticles dried by spray-drying.
在过去三十年里，聚合物纳米颗粒一直是多个领域多项研究的焦点，这些领域包括药物、诊断和化妆品制剂的递送。这些纳米载体能够提高药物的生物利用度和固有溶解度，将不同制剂靶向特定位置，或保护制剂免受外部因素（如辐射和极端pH条件）的影响。尽管人们对这些制剂的开发兴趣浓厚，但它们存在一些缺点，如物理化学稳定性有限，这阻碍了制备方法的扩大规模。在这种情况下，有人提出采用喷雾干燥技术来获得含有聚合物纳米颗粒的粉末组合物，从而规避这一有限的性质。在此背景下，本综述聚焦于与获得喷雾干燥聚合物纳米颗粒相关的最新专利，这些专利根据其方法分为三个不同的组：i）喷雾干燥溶液以获得纳米颗粒，ii）喷雾干燥乳液/分散体以获得纳米颗粒，以及iii）通过喷雾干燥干燥的纳米颗粒。
