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基于Eudragit的智能医疗共聚物系统综述。

A Systematic Overview of Eudragit Based Copolymer for Smart Healthcare.

作者信息

Nikam Aniket, Sahoo Priya Ranjan, Musale Shubham, Pagar Roshani R, Paiva-Santos Ana Cláudia, Giram Prabhanjan Shridhar

机构信息

Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India.

Department of Chemistry, University of Delhi, Delhi 110007, India.

出版信息

Pharmaceutics. 2023 Feb 9;15(2):587. doi: 10.3390/pharmaceutics15020587.

Abstract

Eudragit, synthesized by radical polymerization, is used for enteric coating, precise temporal release, and targeting the entire gastrointestinal system. Evonik Healthcare Germany offers different grades of Eudragit. The ratio of methacrylic acid to its methacrylate-based monomers used in the polymerization reaction defines the final product's characteristics and consequently its potential range of applications. Since 1953, these polymers have been made to use in a wide range of healthcare applications around the world. In this review, we reviewed the "known of knowns and known of unknowns" about Eudragit, from molecule to material design, its characterization, and its applications in healthcare.

摘要

由自由基聚合合成的尤特奇用于肠溶包衣、精确的定时释放以及靶向整个胃肠道系统。德国赢创医疗保健公司提供不同等级的尤特奇。聚合反应中使用的甲基丙烯酸与其甲基丙烯酸酯类单体的比例决定了最终产品的特性,进而决定了其潜在的应用范围。自1953年以来,这些聚合物已在全球广泛的医疗保健应用中得到使用。在本综述中,我们回顾了关于尤特奇从分子到材料设计、其表征以及在医疗保健中的应用的“已知的已知和已知的未知”。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e63/9962897/48acf24cfbde/pharmaceutics-15-00587-g001.jpg

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