Baumann J M, Wacker M
Urol Res. 1979 Sep;7(3):183-8. doi: 10.1007/BF00257204.
The effect of urine, pyrophosphate (PPi), citrate and diphosphonate on the formation, the growth rate or the aggregation of calcium oxalate or calcium phosphate crystals was measured by 4 different methods. The degree of supersaturation and the area of crystal surface present in the test systems were found to be limiting factors for the action of inhibitors. Citrate and PPi proved to be important urinary inhibitors of the growth of calcium oxalate crystals. Comparison between stone formers and healthy controls revealed a significant lack of PPi in urine of male patients. The inhibitory effect of PPi in urine of healthy people was enhanced by unknown factors. This enhancement could not be found in about 60% of the stone patients. Problems relating to measurement and clinical importance of inhibitors are discussed.
通过4种不同方法测定了尿液、焦磷酸盐（PPi）、柠檬酸盐和双膦酸盐对草酸钙或磷酸钙晶体形成、生长速率或聚集的影响。发现测试系统中的过饱和度程度和晶体表面面积是抑制剂作用的限制因素。柠檬酸盐和PPi被证明是草酸钙晶体生长的重要尿液抑制剂。结石形成者与健康对照者的比较显示，男性患者尿液中PPi明显缺乏。健康人尿液中PPi的抑制作用因未知因素而增强。约60%的结石患者未发现这种增强作用。讨论了与抑制剂测量和临床重要性相关的问题。
