Pereţianu D, Dumitrescu C, Lotreanu V
Department of Endocrinology and Applied Immunology, Hospital of the 4th District, Bucharest, Romania.
Med Interne. 1990 Jan-Mar;28(1):41-5.
The association of hyperthyroidism and ulcerative colitis (UC) is presented in two cases: a 61-year-old man and a 54-year-old woman. In the first case the onset of hyperthyroidism was detected at the age of 25, and the onset of ulcerative colitis at the age of 36. The second case presented severe hyperthyroidism started at the age of 51. In the latter case ulcerative colitis had been detected ten year earlier. To our knowledge this report seems to be the first one considering this association from the endocrinological standpoint. The association of these two diseases might suggest that the disturbance of even one organ specific immune lesion implies a wider disorder. Thus one might assume that the association of multiple organ-specific immune diseases represents an unsuccessful attempt to equilibrate the repertoire of idiotypes and anti-idiotypes belonging to the immune network.
本文报告两例甲状腺功能亢进症与溃疡性结肠炎（UC）的关联病例：一名61岁男性和一名54岁女性。第一例中，甲状腺功能亢进症于25岁发病，溃疡性结肠炎于36岁发病。第二例中，严重甲状腺功能亢进症始于51岁，而溃疡性结肠炎在十年前已被诊断出。据我们所知，本报告似乎是从内分泌学角度考虑这种关联的首例报告。这两种疾病的关联可能表明，即使是一个器官特异性免疫病变的紊乱也意味着更广泛的失调。因此，可以假设多种器官特异性免疫疾病的关联代表了平衡免疫网络中独特型和抗独特型库的一次不成功尝试。
