Ghanizadeh Ahmad, Berk Michael
Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical, Sciences, Hafez Hospital, Shiraz, Iran.
Med Gas Res. 2013 Jun 6;3(1):11. doi: 10.1186/2045-9912-3-11.
Hydrogen gas is a bioactive molecule that has a diversity of effects, including anti-apoptotic, anti-inflammatory and anti-oxidative properties; these overlap with the process of neuroprogression in major psychiatric disorders. Specifically, both bipolar disorder and schizophrenia are associated with increased oxidative and inflammatory stress. Moreover, lithium which is commonly administered for treating bipolar disorder has effects on oxidative stress and apoptotic pathways, as do valproate and some atypical antipsychotics for treating schizophrenia. Molecular hydrogen has been studied pre-clinically in animal models for the treatment of some medical conditions including hypoxia and neurodegenerative disorders, and there are intriguing clinical findings in neurological disorders including Parkinson's disease. Therefore, it is hypothesized that administration of hydrogen molecule may have potential as a novel therapy for bipolar disorder, schizophrenia, and other concurrent disorders characterized by oxidative, inflammatory and apoptotic dysregulation.
氢气是一种生物活性分子，具有多种作用，包括抗凋亡、抗炎和抗氧化特性；这些特性与主要精神疾病的神经病变过程相互重叠。具体而言，双相情感障碍和精神分裂症都与氧化应激和炎症应激增加有关。此外，常用于治疗双相情感障碍的锂对氧化应激和凋亡途径有影响，丙戊酸盐和一些用于治疗精神分裂症的非典型抗精神病药物也是如此。分子氢已在动物模型中进行了临床前研究，用于治疗包括缺氧和神经退行性疾病在内的一些医学病症，并且在包括帕金森病在内的神经疾病中也有引人关注的临床发现。因此，有人推测，给予氢分子可能具有作为双相情感障碍、精神分裂症以及其他以氧化、炎症和凋亡失调为特征的并发疾病的新型治疗方法的潜力。
