Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email:
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Annu Rev Biomed Eng. 2021 Jul 13;23:225-248. doi: 10.1146/annurev-bioeng-121219-024239. Epub 2021 Mar 31.
Red blood cell (RBC) hitchhiking is a method of drug delivery that can increase drug concentration in target organs by orders of magnitude. In RBC hitchhiking, drug-loaded nanoparticles (NPs) are adsorbed onto red blood cells and then injected intravascularly, which causes the NPs to transfer to cells of the capillaries in the downstream organ. RBC hitchhiking has been demonstrated in multiple species and multiple organs. For example, RBC-hitchhiking NPs localized at unprecedented levels in the brain when using intra-arterial catheters, such as those in place immediately after mechanical thrombectomy for acute ischemic stroke. RBC hitchhiking has been successfully employed in numerous preclinical models of disease, ranging from pulmonary embolism to cancer metastasis. In addition to summarizing the versatility of RBC hitchhiking, we also describe studies into the surprisingly complex mechanisms of RBC hitchhiking as well as outline future studies to further improve RBC hitchhiking's clinical utility.
红细胞搭便车是一种药物传递方法，可以将药物浓度提高几个数量级。在红细胞搭便车中，载药纳米颗粒（NPs）被吸附到红细胞上，然后静脉内注射，导致 NPs 转移到下游器官的毛细血管细胞。红细胞搭便车已在多种物种和多个器官中得到证实。例如，当使用动脉内导管（例如急性缺血性脑卒中机械血栓切除术后立即放置的导管）时，红细胞搭便车的 NPs 以前所未有的水平定位于大脑。红细胞搭便车已成功应用于多种疾病的临床前模型，从肺栓塞到癌症转移。除了总结红细胞搭便车的多功能性外，我们还描述了对红细胞搭便车令人惊讶的复杂机制的研究，并概述了未来的研究，以进一步提高红细胞搭便车的临床实用性。
