San Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California 92120, USA.
J Int Neuropsychol Soc. 2012 Nov;18(6):986-95. doi: 10.1017/S1355617712000781. Epub 2012 Jul 30.
Although individuals with Parkinson's disease (PD) evidence moderate deficits in prospective memory (PM), it is not known whether PM deficits confer an increased risk of poorer everyday functioning. In the current study, 33 individuals with PD and 26 demographically similar normal controls (NC) were administered performance-based and self-report measures of PM and everyday functioning, including medication and financial management. As compared to NC, PD participants demonstrated significantly lower scores on performance-based measures of PM and financial capacity, worse performance at a trend level on performance-based medication management and endorsed significantly greater self-reported declines in PM and instrumental activities of daily living (iADLs). In the PD sample, the laboratory measure of PM significantly correlated with performance-based measures of financial capacity and medication management and a self-report measure of medication management. Self-reported PM failures significantly correlated with perceived declines in iADLs, worse medication management, and poorer health-related quality of life. Although future studies are needed to examine the incremental ecological validity of PM in PD, findings from this study extend prior research by providing preliminary evidence that PM impairment may play a significant role in a range of critical everyday functions in PD.
尽管帕金森病（PD）患者在前瞻性记忆（PM）方面表现出中等程度的缺陷，但目前尚不清楚 PM 缺陷是否会增加日常生活功能较差的风险。在当前的研究中，33 名 PD 患者和 26 名人口统计学相似的正常对照组（NC）接受了基于表现和自我报告的 PM 和日常功能评估，包括药物和财务管理。与 NC 相比，PD 参与者在基于表现的 PM 和财务能力评估中得分明显较低，在基于表现的药物管理方面表现略差，并且自我报告的 PM 和工具性日常生活活动（iADL）下降幅度明显更大。在 PD 样本中，PM 的实验室测量与财务能力和药物管理的基于表现的测量以及药物管理的自我报告测量显著相关。自我报告的 PM 失败与感知到的 iADL 下降、更差的药物管理和较差的健康相关生活质量显著相关。尽管未来的研究需要检验 PM 在 PD 中的增量生态有效性，但这项研究的结果通过提供初步证据扩展了先前的研究，表明 PM 损伤可能在 PD 的一系列关键日常功能中起着重要作用。
