Department of Medicine, Steel Memorial Hirohata Hospital, Himeji.
Department of Gastroenterology, Shimane University School of Medicine, Izumo, Japan.
Curr Opin Allergy Clin Immunol. 2020 Jun;20(3):311-315. doi: 10.1097/ACI.0000000000000635.
Although several reviews concerning diagnosis and treatment of eosinophilic esophagitis (EoE) have been presented, there are few in regard to eosinophilic gastroenteritis (EGE). Fortunately, findings related to epidemiology, as well as diagnosis and treatment of this disease have recently been increasing.
The rates of incidence of both EoE and EGE have been reported to be increasing. For accurate diagnosis, plasma concentrations of thymic stromal lymphopoietin and IL-33 may be useful as biomarkers, though consensus has not been reached, while increased eosinophil infiltration in gastrointestinal tissue remains a critical factor. Topical glucocorticoid administration, an elimination diet, and molecular target therapy with neutralizing antibodies are potentially effective therapies that have recently been evaluated.
As seen with other allergic diseases, EGE seems to be increasing. Several research projects regarding diagnosis and treatment of the disease are currently in progress.
目的综述：尽管已有多篇关于嗜酸细胞性食管炎（EoE）的诊断和治疗的综述，但有关嗜酸细胞性胃肠炎（EGE）的却很少。幸运的是，最近有关该病的流行病学、诊断和治疗的研究结果不断增多。
最新发现：EoE 和 EGE 的发病率报告均呈上升趋势。对于准确诊断，胸腺基质淋巴细胞生成素和 IL-33 的血浆浓度可作为生物标志物，但尚未达成共识，而胃肠道组织中嗜酸性粒细胞浸润的增加仍然是一个关键因素。局部糖皮质激素给药、消除饮食和中和抗体的分子靶向治疗是最近评估的潜在有效治疗方法。
总结：与其他过敏性疾病一样，EGE 似乎也在增加。目前正在进行多项关于该病诊断和治疗的研究项目。
