Chulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok, Thailand.
Org Biomol Chem. 2012 Sep 21;10(35):7220-6. doi: 10.1039/c2ob25959a. Epub 2012 Jul 30.
Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1-3 were addressed by Mosher's method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated.
从泰国药用植物三叶芫花（Tiliacora triandra）内生真菌枝孢属（Dothideomycete sp.）中分离得到的化合物 1 和 2 是吖啶酮衍生物，3 是新型三环多酮，此外还有一个已知的吖啶酮 austdiol（4）。化合物 3 是第一个具有三环 6,6,6 环系统的多酮，类似于萜烯骨架。通过 Mosher 法和与从同一真菌中分离得到的已知吖啶酮的生物合成类似性，确定了 1-3 中立体中心的绝对构型。对分离得到的化合物进行了细胞毒性和抗菌活性评价。
