Li Zhongqi, Jin Ketao, Yu Xiongfei, Teng Xiaodong, Zhou Hua, Wang Yanli, Teng Lisong, Cao Feilin
Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou.
Oncol Lett. 2011 Jul;2(4):649-652. doi: 10.3892/ol.2011.296. Epub 2011 May 3.
Extranodal follicular dendritic cell (FDC) sarcomas are not a common phenomenon. Due to the scarcity of the identified cases reported in the literature, FDC is probably under-recognized and commonly misdiagnosed. The diagnosis of FDC sarcomas is based on node-based spindle cell lesions, and the expression of CD21, CD35 and clusterin. The most commonly involved extranodal sites include the oral cavity, tonsil, gastrointestinal tract and liver. With the aid of immunohistochemical analysis and the two most reliable FDC markers, CD21 and CD35, the diagnostic accuracy has improved. When FDC sarcoma is suspected histologically, immunohistochemical stains for FDC differentiation should be performed to avoid potential misdiagnosis. This case report concerns the evaluation of a 43-year-old male Chinese patient with a large extranodal FDC sarcoma (20×18×9 cm) in the mesentery with elevated serum CA125 (76.9 U/ml). The diagnosis and treatment of this disease are also discussed.
结外滤泡树突状细胞（FDC）肉瘤并不常见。由于文献报道的确诊病例稀少，FDC肉瘤可能未得到充分认识且常被误诊。FDC肉瘤的诊断基于结节性梭形细胞病变以及CD21、CD35和簇集蛋白的表达。最常累及的结外部位包括口腔、扁桃体、胃肠道和肝脏。借助免疫组织化学分析以及两种最可靠的FDC标志物CD21和CD35，诊断准确性有所提高。当组织学上怀疑为FDC肉瘤时，应进行FDC分化的免疫组织化学染色以避免潜在的误诊。本病例报告涉及一名43岁中国男性患者，其肠系膜有一个巨大的结外FDC肉瘤（20×18×9 cm），血清CA125升高（76.9 U/ml）。本文还讨论了该疾病的诊断和治疗。
