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鸡感染 MDV 后的组蛋白甲基化分析及通路预测。

Histone methylation analysis and pathway predictions in chickens after MDV infection.

机构信息

Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, United States of America.

出版信息

PLoS One. 2012;7(7):e41849. doi: 10.1371/journal.pone.0041849. Epub 2012 Jul 26.

DOI:10.1371/journal.pone.0041849
PMID:22848633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3406056/
Abstract

Marek's disease (MD) is a lymphoproliferative disease in chicken induced by Marek's disease virus (MDV). Although studies have focused on the genetic differences between the resistant and susceptible chicken, less is known about the role of epigenetic factors in MD. In this study, genome-wide histone modifications in the non-MHC-associated resistant and susceptible chicken lines were examined. We found that tri-methylation at histone H3 Lys4 (H3K4me3) enrichment is positively correlated with the expression of protein coding genes as well as microRNA (miRNA) genes, whereas tri-methylation at histone H3 Lys27 (H3K27me3) exhibits a negative correlation. By identifying line-specific histone modifications in MDV infection, we found unique H3K4me3 islands in the resistant chicken activated genes, which are related to immune response and cell adhesion. Interestingly, we also found some miRNAs from unique H3K27me3 patterns in the susceptible chickens that targeted genes involved in 5-hydroxytryptamine (5-HT)-receptor and adrenergic receptor pathways. In conclusion, dynamic line-specific histone modifications in response to MDV infection suggested that intrinsic epigenetic mechanisms may play a role in MD-resistance and -susceptibility.

摘要

马立克氏病（MD）是由马立克氏病病毒（MDV）引起的鸡的淋巴组织增生性疾病。虽然研究集中在抗性和易感鸡之间的遗传差异上，但对表观遗传因素在 MD 中的作用知之甚少。在这项研究中，研究了非 MHC 相关抗性和易感鸡系中的全基因组组蛋白修饰。我们发现组蛋白 H3 Lys4 三甲基化（H3K4me3）富集与蛋白质编码基因和 microRNA（miRNA）基因的表达呈正相关，而组蛋白 H3 Lys27 三甲基化（H3K27me3）呈负相关。通过鉴定 MDV 感染中的谱系特异性组蛋白修饰，我们发现了抗性鸡激活基因中的独特 H3K4me3 岛，这些岛与免疫反应和细胞黏附有关。有趣的是，我们还发现了易感鸡中一些独特的 H3K27me3 模式下的 miRNA，这些 miRNA 靶向参与 5-羟色胺（5-HT）受体和肾上腺素能受体途径的基因。总之，对 MDV 感染的谱系特异性动态组蛋白修饰表明，内在的表观遗传机制可能在 MD 的抗性和易感性中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0a/3406056/4e9894bc086e/pone.0041849.g008.jpg
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