子代肥胖、脂肪生成和食欲的发育编程。
Developmental programming of offspring obesity, adipogenesis, and appetite.
作者信息
Ross Michael G, Desai Mina
机构信息
Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, USA.
出版信息
Clin Obstet Gynecol. 2013 Sep;56(3):529-36. doi: 10.1097/GRF.0b013e318299c39d.
Abstract
A newly recognized primary cause of the obesity epidemic is the developmental programming effects of infants born to mothers with obesity or gestational diabetes, intrauterine growth-restricted newborns, and offspring exposed to environmental toxins including bisphenol A. The mechanisms which result in offspring obesity include the programming of the hypothalamic appetite pathway and adipogenic signals regulating lipogenesis. Processes include nutrient sensors, epigenetic modifications, and alterations in stem cell precursors of both appetite/satiety neurons and adipocytes which are modulated to potentiate offspring obesity. Future strategies for the prevention and therapy of obesity must address programming effects of the early life environment.
摘要
肥胖流行新发现的一个主要原因是，母亲患有肥胖症或妊娠糖尿病的婴儿、宫内生长受限的新生儿以及接触包括双酚A在内的环境毒素的后代所产生的发育编程效应。导致后代肥胖的机制包括下丘脑食欲通路的编程以及调节脂肪生成的脂肪生成信号。这些过程包括营养传感器、表观遗传修饰，以及食欲/饱腹感神经元和脂肪细胞的干细胞前体的改变，这些改变被调节以增强后代肥胖。肥胖预防和治疗的未来策略必须应对早期生活环境的编程效应。
相似文献
1
Developmental programming of offspring obesity, adipogenesis, and appetite.
Clin Obstet Gynecol. 2013 Sep;56(3):529-36. doi: 10.1097/GRF.0b013e318299c39d.
2
Impact of fetal and neonatal environment on beta cell function and development of diabetes.
Acta Obstet Gynecol Scand. 2014 Nov;93(11):1109-22. doi: 10.1111/aogs.12504. Epub 2014 Oct 10.
3
Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus.
Nutr Rev. 2013 Oct;71 Suppl 1:S88-94. doi: 10.1111/nure.12057.
4
Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet.
Semin Reprod Med. 2011 May;29(3):237-45. doi: 10.1055/s-0031-1275517. Epub 2011 Jun 27.
5
Developmental programming of appetite/satiety.
Ann Nutr Metab. 2014;64 Suppl 1:36-44. doi: 10.1159/000360508. Epub 2014 Jul 23.
6
Maternal food restriction-induced intrauterine growth restriction in a rat model leads to sex-specific adipogenic programming.
FASEB J. 2020 Dec;34(12):16073-16085. doi: 10.1096/fj.202000985RR. Epub 2020 Oct 13.
7
Maternal obesity and prenatal programming.
Mol Cell Endocrinol. 2016 Nov 5;435:2-6. doi: 10.1016/j.mce.2016.07.002. Epub 2016 Jul 5.
8
In vivo and in vitro bisphenol A exposure effects on adiposity.
J Dev Orig Health Dis. 2018 Dec;9(6):678-687. doi: 10.1017/S2040174418000600. Epub 2018 Aug 29.
9
Fetal programming and gestational diabetes mellitus.
Placenta. 2016 Dec;48 Suppl 1:S54-S60. doi: 10.1016/j.placenta.2015.11.015. Epub 2015 Dec 12.
10
Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes.
Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108. doi: 10.1111/aogs.12494. Epub 2014 Sep 30.
引用本文的文献
1
Dual Effects of Maternal Diet and Perinatal Organophosphate Flame Retardant Treatment on Offspring Development, Behavior and Metabolism.
Toxics. 2025 Jul 29;13(8):639. doi: 10.3390/toxics13080639.
2
Unraveling Metabolic Syndrome in Youth: The Obesity Epidemic's Hidden Complication.
Children (Basel). 2025 Apr 8;12(4):482. doi: 10.3390/children12040482.
3
Endocrine Disruptors in Child Obesity and Related Disorders: Early Critical Windows of Exposure.
Curr Nutr Rep. 2025 Jan 8;14(1):14. doi: 10.1007/s13668-024-00604-1.
4
Composition of Breast Milk in Women with Obesity.
J Clin Med. 2024 Nov 18;13(22):6947. doi: 10.3390/jcm13226947.
5
Human Breast Milk Exosomes: Affecting Factors, Their Possible Health Outcomes, and Future Directions in Dietetics.
Nutrients. 2024 Oct 17;16(20):3519. doi: 10.3390/nu16203519.
6
Maternal diet during pregnancy and adaptive changes in the maternal and fetal pancreas have implications for future metabolic health.
Front Endocrinol (Lausanne). 2024 Sep 23;15:1456629. doi: 10.3389/fendo.2024.1456629. eCollection 2024.
7
A single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning.
Commun Biol. 2024 Jun 29;7(1):787. doi: 10.1038/s42003-024-06448-3.
8
Substance P Concentration in Gestational Diabetes and Excessive Gestational Weight Gain and Its Impact on Neonatal Anthropometry.
Int J Mol Sci. 2024 Mar 28;25(7):3759. doi: 10.3390/ijms25073759.
9
Associations of parental preconception and maternal pregnancy urinary phthalate biomarker and bisphenol-a concentrations with child eating behaviors.
Int J Hyg Environ Health. 2024 Apr;257:114334. doi: 10.1016/j.ijheh.2024.114334. Epub 2024 Feb 13.
10
The Effect of Holder Pasteurization and Different Variants on Breast Milk Antioxidants.
Antioxidants (Basel). 2023 Oct 13;12(10):1857. doi: 10.3390/antiox12101857.
本文引用的文献
1
Peroxisome proliferator-activated receptor gamma modulation and lipogenic response in adipocytes of small-for-gestational age offspring.
Nutr Metab (Lond). 2012 Jun 22;9(1):62. doi: 10.1186/1743-7075-9-62.
2
Mechanism of programmed obesity in intrauterine fetal growth restricted offspring: paradoxically enhanced appetite stimulation in fed and fasting states.
Reprod Sci. 2012 Apr;19(4):423-30. doi: 10.1177/1933719111424448. Epub 2012 Feb 16.
3
Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: neurotrophic effects of leptin and insulin.
Brain Res. 2011 Mar 10;1378:29-42. doi: 10.1016/j.brainres.2010.12.080. Epub 2011 Jan 6.
4
Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and alphaMSH-neurons and impairs hypothalamic response to fed/fasting conditions in weaned rats.
Diabetes Obes Metab. 2010 May;12(5):403-13. doi: 10.1111/j.1463-1326.2009.01174.x.
5
Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors.
Biochim Biophys Acta. 2009 Jul;1793(7):1128-43. doi: 10.1016/j.bbamcr.2009.03.009. Epub 2009 Apr 5.
6
Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring.
Reprod Sci. 2008 Oct;15(8):785-96. doi: 10.1177/1933719108318597.
7
Perinatal programming of obesity.
Semin Perinatol. 2008 Oct;32(5):371-4. doi: 10.1053/j.semperi.2008.08.004.
8
Programmed alterations in hypothalamic neuronal orexigenic responses to ghrelin following gestational nutrient restriction.
Reprod Sci. 2008 Sep;15(7):702-9. doi: 10.1177/1933719108316982. Epub 2008 Jun 18.
9
Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction.
Endocrinology. 2008 Jul;149(7):3617-25. doi: 10.1210/en.2007-1388. Epub 2008 Mar 27.
10
Maternal bisphenol-A levels at delivery: a looming problem?
J Perinatol. 2008 Apr;28(4):258-63. doi: 10.1038/sj.jp.7211913. Epub 2008 Feb 14.
Zotero 插件