Chen Le, Knowlton A A
Molecular and Cellular Cardiology Division, Department of Mediicine, University of California, Davis, CA, USA.
Congest Heart Fail. 2011 Nov-Dec;17(6):257-61. doi: 10.1111/j.1751-7133.2011.00255.x.
Mitochondria have been widely studied for their critical role in cellular metabolism, energy production, and cell death. New developments in research on mitochondria derived from studies in yeast have led to the discovery of entirely new mitochondrial processes that have implications for mitochondrial function in heart failure. Recent studies have identified that maintaining normal mitochondrial morphology and function depends on the dynamic balance of mitochondrial fusion and fission (division). Mitochondrial fusion and fission are constant ongoing processes, which are essential for the maintenance of normal mitochondrial function. Studies in heart failure have been limited but suggest a possible reduction in mitochondrial fusion. As mitochondrial fusion and fission have important links to apoptosis, a key mechanism of loss of cardiac myocytes in heart failure, there are many implications for both heart failure research and treatment.
线粒体因其在细胞代谢、能量产生和细胞死亡中的关键作用而受到广泛研究。源于酵母研究的线粒体研究新进展，已导致发现了全新的线粒体过程，这些过程对心力衰竭中线粒体功能具有重要意义。最近的研究已确定，维持正常的线粒体形态和功能取决于线粒体融合与裂变（分裂）的动态平衡。线粒体融合和裂变是持续不断的过程，对于维持正常的线粒体功能至关重要。关于心力衰竭的研究有限，但提示线粒体融合可能减少。由于线粒体融合和裂变与细胞凋亡（心力衰竭中心肌细胞丧失的关键机制）有重要联系，这对心力衰竭的研究和治疗都有诸多启示。
