National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
J Mol Med (Berl). 2010 Oct;88(10):971-9. doi: 10.1007/s00109-010-0674-6. Epub 2010 Sep 14.
Mitochondria are dynamic organelles that usually exist in extensive and interconnected networks that undergo constant remodeling through fission and fusion. These processes are governed by distinct sets of proteins whose mechanism and regulation we are only beginning to fully understand. Early studies on mitochondrial dynamics were performed in yeast and simple mammalian cell culture models that allowed easy visualization of these intricate networks. Equipped with this core understanding, the field is now expanding into more complex systems. Cardiac cells are a particularly interesting example because they have unique energetic and spatial demands that make the study of their mitochondria both challenging and potentially very fruitful. This review will provide an overview of mitochondrial fission and fusion as well as recent developments in the understanding of these processes in the heart.
线粒体是动态细胞器，通常存在于广泛且相互连接的网络中，通过分裂和融合不断进行重塑。这些过程由不同的蛋白质组控制，我们才刚刚开始全面理解其机制和调控。早期的线粒体动力学研究是在酵母和简单的哺乳动物细胞培养模型中进行的，这些模型可以方便地观察到这些复杂的网络。有了这些核心认识，该领域现在正在向更复杂的系统扩展。心肌细胞是一个特别有趣的例子，因为它们具有独特的能量和空间需求，使得对其线粒体的研究既具有挑战性，又具有潜在的非常丰富的成果。本综述将概述线粒体的分裂和融合，以及近年来对心脏中这些过程的理解的最新进展。
