Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy.
Int J Mol Sci. 2023 Feb 8;24(4):3414. doi: 10.3390/ijms24043414.
The most common alterations affecting mitochondria, and associated with cardiac pathological conditions, implicate a long list of defects. They include impairments of the mitochondrial electron transport chain activity, which is a crucial element for energy formation, and that determines the depletion of ATP generation and supply to metabolic switches, enhanced ROS generation, inflammation, as well as the dysregulation of the intracellular calcium homeostasis. All these signatures significantly concur in the impairment of cardiac electrical characteristics, loss of myocyte contractility and cardiomyocyte damage found in cardiac diseases. Mitochondrial dynamics, one of the quality control mechanisms at the basis of mitochondrial fitness, also result in being dysregulated, but the use of this knowledge for translational and therapeutic purposes is still in its infancy. In this review we tried to understand why this is, by summarizing methods, current opinions and molecular details underlying mitochondrial dynamics in cardiac diseases.
最常见的影响线粒体的改变与心脏病理状况有关，涉及一长串缺陷。这些缺陷包括线粒体电子传递链活性的损伤，这是能量形成的关键因素，决定了 ATP 生成和代谢转换供应的减少、ROS 生成的增加、炎症以及细胞内钙稳态的失调。所有这些特征都显著导致了心脏疾病中心脏电特性的损伤、肌细胞收缩力的丧失和心肌细胞的损伤。线粒体动力学是线粒体适应性的基础之一，也是一种质量控制机制，但将这方面的知识应用于转化和治疗目的仍处于起步阶段。在这篇综述中，我们试图通过总结方法、目前的观点和心脏疾病中线粒体动力学的分子细节来理解为什么会这样。
