Affiliated Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, China
Int J Psychiatry Med. 2012;43(2):189-96. doi: 10.2190/PM.43.2.g.
To explore the correlation between brain event-related potentials (ERPs) and psychiatric symptoms in patients with amphetamine-type stimulants (ATS) dependence.
Using Galileo Sirius 32-channels digital-evoked potential system, we measured the auditory P300 ERP in 40 ATS dependence subjects and 30 normal controls, respectively. Symptom Checklist 90 (SCL-90) was used to rate the psychiatric symptoms in the subjects.
In ATS dependence subjects, the latency of N2, latency of P3, and inter-peak latency of P2-N2 were significantly longer than those in controls, respectively (P < 0.05). The amplitude of P300 in ATS dependence subjects was significantly lower than that in controls (P < 0.01). Besides, significantly lower amplitude of P3 and longer latency of P3 were found in ATS dependence subjects suffering from psychiatric symptoms than those without psychotic symptoms (P < 0.05). Furthermore, in ATS dependence subjects, the latency of N2 was negatively correlated with the scores of anxiety factor (r = -0.366) and paranoid ideation factor of SCL-90; the latency of P3 negatively correlated with the scores of psychoticism (r = -0.430) and somatization (r = -0.397) factor; also, the amplitude of P3 was negatively correlated with the score ofpsychoticism factor (r = -0.486).
These findings suggest cognitive dysfunction may be one of results of ATS dependence.
探讨苯丙胺类兴奋剂（ATS）依赖患者脑事件相关电位（ERP）与精神症状的相关性。
采用 Galileo Sirius 32 导数字化诱发电位系统，分别对 40 例 ATS 依赖者和 30 例正常对照者进行听觉 P300 ERP 检测，同时采用症状自评量表（SCL-90）评定受试者的精神症状。
与对照组比较，ATS 依赖者 N2 潜伏期、P3 潜伏期及 P2-N2 波峰间潜伏期延长，P300 波幅降低，差异均有统计学意义（P < 0.05）。伴有精神症状的 ATS 依赖者 P3 波幅降低和 P3 潜伏期延长更明显，差异有统计学意义（P < 0.05）。此外，ATS 依赖者 N2 潜伏期与 SCL-90 焦虑因子分（r = -0.366）和偏执因子分呈负相关，P3 潜伏期与精神病性因子分（r = -0.430）和躯体化因子分呈负相关，P3 波幅与精神病性因子分呈负相关（r = -0.486）。
认知功能障碍可能是 ATS 依赖的结果之一。
