Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
J Infect Dis. 2012 Oct 1;206(7):1103-10. doi: 10.1093/infdis/jis458. Epub 2012 Jul 30.
Anal cancer is caused by human papillomavirus (HPV), yet little is known about anal HPV infection among healthy young women.
A total of 2017 sexually active women in the control arm of an HPV-16/18 vaccine trial had a single anal specimen collected by a clinician at the 4-year study visit. Samples were tested for HPV by SPF(10) PCR/DEIA/LiPA(25), version 1.
A total of 4% of women had HPV-16, 22% had oncogenic HPV, and 31% had any HPV detected in an anal specimen. The prevalence of anal HPV was higher among women who reported anal intercourse, compared with those who did not (43.4% vs 28.4%; P< .001). Among women who reported anal intercourse, cervical HPV (adjusted odds ratio [aOR], 5.3 [95% confidence interval {CI}, 3.4-8.2]), number of sex partners (aOR, 2.2 [95% CI, 1.1-4.6] for ≥ 4 partners), and number of anal intercourse partners (aOR, 1.9 [95% CI, 1.1-3.3] for ≥ 2 partners) were independent risk factors for anal HPV detection. Among women who reported no anal intercourse, cervical HPV (aOR, 4.7 [95% CI, 3.7-5.9]), number of sex partners (aOR, 2.4 [95% CI, 1.7-3.4] for ≥ 4 partners), and report of anal fissures (aOR, 2.3 [95% CI, 1.1-4.8]) were associated with an increased odds of anal HPV detection.
Anal HPV is common among young women, even those who report no anal sex, and was associated with cervical HPV infection. Anal fissures in women who report never having had anal intercourse may facilitate HPV exposure.
NCT00128661.
肛门癌是由人乳头瘤病毒（HPV）引起的，但对于健康年轻女性中的肛门 HPV 感染知之甚少。
在 HPV-16/18 疫苗试验的对照组中，共有 2017 名有性行为的女性在 4 年研究访问时由临床医生采集了单一的肛门标本。通过 SPF(10)PCR/DEIA/LiPA(25)、版本 1 对样本进行 HPV 检测。
共有 4%的女性有 HPV-16，22%有致癌 HPV，31%的肛门标本检测到任何 HPV。与没有肛交的女性相比，报告有肛交的女性的肛门 HPV 患病率更高（43.4%对 28.4%；P<.001）。在报告有肛交的女性中，宫颈 HPV（调整后的优势比[aOR]，5.3[95%置信区间{CI}，3.4-8.2]）、性伴侣数量（aOR，≥4 个伴侣为 2.2[95%CI，1.1-4.6]）和肛交伴侣数量（aOR，≥2 个伴侣为 1.9[95%CI，1.1-3.3]）是肛门 HPV 检测的独立危险因素。在报告没有肛交的女性中，宫颈 HPV（aOR，4.7[95%CI，3.7-5.9]）、性伴侣数量（aOR，≥4 个伴侣为 2.4[95%CI，1.7-3.4]）和报告的肛门裂（aOR，2.3[95%CI，1.1-4.8]）与肛门 HPV 检测几率增加相关。
肛门 HPV 在年轻女性中很常见，即使是那些报告没有肛交的女性，并且与宫颈 HPV 感染有关。报告从未有过肛交的女性中的肛门裂可能会促进 HPV 暴露。
NCT00128661。
