School of Pharmaceutical Sciences, University of Science Malaysia, 11700 Penang, Malaysia.
Reprod Biol. 2012 Jul;12(2):247-55. doi: 10.1016/s1642-431x(12)60089-8.
The objective of this research was to study the ameliorative effects of a standardized quassinoid-rich extract (TAF 273) of Eurycoma longifolia root on some reproductive disorders in female rats. An irregular estrous cycle and ovarian cystic follicles were induced in 21-day-old females by the daily administration of testosterone (10 mg/kg, sc) for three weeks. The hormone-treated rats exhibited persistent diestrous as well as ovaries containing cystic follicles. Upon treatment with TAF 273, fewer animals showed irregular estrous cycles and there was less follicular morphological damage. The reversal effect may be derived from the anti-estrogenic properties of the plant quassinoids.
本研究旨在探讨标准武靴藤根喹诺里西啶类生物碱提取物（TAF 273）对雌性大鼠某些生殖功能紊乱的改善作用。通过连续 3 周每天给 21 天大的雌性大鼠皮下注射 10mg/kg 的睾酮诱导出不规则动情周期和卵巢囊性滤泡。经激素处理的大鼠呈现持续间情期和含有囊性滤泡的卵巢。用 TAF 273 处理后，表现出不规则动情周期的动物数量减少，滤泡形态损伤减少。这种逆转作用可能源于植物喹诺里西啶类生物碱的抗雌激素特性。
