Abdulghani Mahfoudh A M, Alshehade Salah Abdulrazak, Kamran Sareh, Alshawsh Mohammed Abdullah
Faculty of Medicine and Health Sciences, University of Science and Technology, Aden, Yemen.
Department of Pharmacology & Toxicology, Unaizah College of Pharmacy, Qassim University, Al Qassim 51911, Saudi Arabia.
Heliyon. 2022 Oct 5;8(10):e10967. doi: 10.1016/j.heliyon.2022.e10967. eCollection 2022 Oct.
Monosodium glutamate (MSG) is commonly used worldwide as a food flavour enhancer by the food industry. The current study investigated the toxic effects of MSG on the uterus in adult female Sprague Dawley rats and using MCF-7 and MDA-MB-231 cells, computational toxicity and molecular docking. The average levels of progesterone and oestrogen in the MSG-treated animals significantly altered. Besides, the average uterine lumen area (μm) was smaller than the control group. MSG showed high-affinity binding to acetylcholine receptors and disrupted the normal nerve signal with a predicted LD50 of 4500 mg/kg. MSG also demonstrated good binding affinity to human oestrogen receptors beta and some other proteins that have an oxidative stress role in the female reproductive organs. Therefore, a precaution should be taken when utilising this compound, especially for females under the risk factor of hormonal abnormality.
味精（MSG）在全球范围内被食品工业广泛用作食品风味增强剂。本研究调查了味精对成年雌性斯普拉格-道利大鼠子宫的毒性作用，并使用MCF-7和MDA-MB-231细胞进行了计算毒性和分子对接研究。经味精处理的动物体内孕酮和雌激素的平均水平发生了显著变化。此外，平均子宫腔面积（μm）小于对照组。味精显示出与乙酰胆碱受体的高亲和力结合，并以预测的半数致死剂量4500 mg/kg破坏正常神经信号。味精还表现出与人雌激素受体β以及其他一些在女性生殖器官中具有氧化应激作用的蛋白质的良好结合亲和力。因此，在使用这种化合物时应采取预防措施，特别是对于有激素异常风险因素的女性。
