Ndc80 蛋白 N 端尾部在酿酒酵母动粒-微管相互作用中具有冗余功能。
A redundant function for the N-terminal tail of Ndc80 in kinetochore-microtubule interaction in Saccharomyces cerevisiae.
机构信息
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, University of Virginia, Charlottesville, VA 22906, USA.
出版信息
Genetics. 2012 Oct;192(2):753-6. doi: 10.1534/genetics.112.143818. Epub 2012 Jul 30.
Abstract
The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating a redundant function for the Ndc80 and Dam1 complexes in vivo.
摘要
Ndc80 的 N 端尾部对于人细胞中的动粒-微管结合是必需的，但在酵母中并不需要它来维持生存。我们表明，酵母 Ndc80 尾部对于有丝分裂的适时进行和染色体的准确分离是必需的。当细胞受到 Dam1 限制时，尾部是必需的，这表明 Ndc80 和 Dam1 复合物在体内具有冗余功能。
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