Ramachandra L, Kudva Ranjini, Rao B H Anand, Agrawal Saurabh
Indian J Surg. 2011 Aug;73(4):287-90. doi: 10.1007/s12262-011-0283-9. Epub 2011 May 5.
The present study was done to compare diagnostic yield by fine needle non aspiration technique (FNNAC) with Fine Needle Aspiration cytology (FNAC) of lesions in thyroid gland. FNNAC and FNAC both were performed on 69 patients presenting with thyroid lesions, except those suffering from thyrotoxicosis. Smears were then cytologically interpreted by a single pathologist as unsuitable, diagnostically adequate or diagnostically superior for opinion, without the knowledge of sampling method employed. Slides were evaluated for following aspects namely cellularity, presence of colloid, inflammatory cell, hemosiderin laden macrophages, papillary clusters nuclear overlapping, nuclear grooving, hurthle cells. FNNAC gave better results in form of better quality of cellularity and less field obscurity by blood in lesions of thyroid. Diagnostically superior specimens were obtained more frequently by FNNAC, so this technique should be used alone or in tandem with FNAC for better diagnostic yield.
本研究旨在比较甲状腺病变的细针非抽吸技术（FNNAC）与细针穿刺抽吸细胞学检查（FNAC）的诊断率。除甲状腺毒症患者外，对69例甲状腺病变患者同时进行了FNNAC和FNAC检查。涂片由一名病理学家在不知道所采用采样方法的情况下，从细胞学角度解释为不适合、诊断充分或诊断性优越，以供参考。对玻片从以下几个方面进行评估，即细胞数量、胶体的存在、炎性细胞、含铁血黄素巨噬细胞、乳头状簇核重叠、核沟、许特莱细胞。FNNAC在甲状腺病变中，细胞数量质量更好且病变内血液造成的视野模糊更少，结果更佳。FNNAC更频繁地获得诊断性优越的标本，因此该技术应单独使用或与FNAC联合使用以提高诊断率。
