氟喹诺酮类药物CI-960、PD 131628、司帕沙星、氧氟沙星和环丙沙星的抗葡萄球菌活性。

Antistaphylococcal activity of the fluoroquinolones CI-960, PD 131628, sparfloxacin, ofloxacin and ciprofloxacin.

作者信息

Barry A L, Fuchs P C

机构信息

Clinical Microbiology Institute, Tualatin, Oregon 97062.

出版信息

Eur J Clin Microbiol Infect Dis. 1991 Mar;10(3):168-71. doi: 10.1007/BF01964451.

DOI:10.1007/BF01964451

PMID:2060518

Abstract

Five fluoroquinolones were tested against 300 staphylococci from a wide variety of US medical centers including 150 strains resistant to penicillinase-resistant penicillins (PRP-resistant). Ten ciprofloxacin-resistant strains of PRP-resistant Staphylococcus aureus were relatively resistant to the other fluoroquinolones, but the remaining 290 isolates were susceptible to all five drugs at established or anticipated breakpoint concentrations. The relative potency of the study drugs could be ranked as follows: CI-960 greater than PD 131628 greater than sparfloxacin greater than ciprofloxacin greater than ofloxacin. All five drugs were bactericidal against PRP-resistant and PRP-susceptible staphylococci.

摘要

对来自美国多个医疗中心的300株葡萄球菌进行了五种氟喹诺酮类药物的测试，其中包括150株对耐青霉素酶青霉素耐药（PRP耐药）的菌株。10株对PRP耐药的耐环丙沙星金黄色葡萄球菌菌株对其他氟喹诺酮类药物也相对耐药，但其余290株分离菌在既定或预期的折点浓度下对所有五种药物均敏感。研究药物的相对效力可按以下顺序排列：CI-960＞PD 131628＞司帕沙星＞环丙沙星＞氧氟沙星。所有五种药物对PRP耐药和PRP敏感的葡萄球菌均有杀菌作用。