糖尿病性血管病变与血管生成缺陷。
Diabetic angiopathy and angiogenic defects.
作者信息
Xu Ling, Kanasaki Keizo, Kitada Munehiro, Koya Daisuke
机构信息
Division of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
出版信息
Fibrogenesis Tissue Repair. 2012 Aug 1;5(1):13. doi: 10.1186/1755-1536-5-13.
Diabetes is one of the most serious health problems in the world. A major complication of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. In this review, we focus on angiogenesis abnormalities in diabetic complications and discuss its benefits and drawbacks as a therapeutic target for diabetic vascular complications. Additionally, we discuss glucose metabolism defects that are associated with abnormal angiogenesis in atypical diabetic complications such as cancer.
糖尿病是世界上最严重的健康问题之一。糖尿病的一个主要并发症是血管疾病，称为血管病变，其特征是异常血管生成。在本综述中，我们重点关注糖尿病并发症中的血管生成异常，并讨论其作为糖尿病血管并发症治疗靶点的利弊。此外，我们还讨论了非典型糖尿病并发症（如癌症）中与异常血管生成相关的葡萄糖代谢缺陷。
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