Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria.
Scand J Med Sci Sports. 2012 Oct;22(5):e79-85. doi: 10.1111/j.1600-0838.2012.01499.x. Epub 2012 Aug 1.
Intermittent hypoxia (IH) is a promising approach to induce acclimatization and hence lower the risk of developing acute mountain sickness (AMS). We hypothesized that a short-term IH protocol in normobaric hypoxia (7 × 1 h to 4500 m) effectively increases the hypoxic ventilatory response (HVR) and reduces the incidence and severity of AMS. Therefore, 26 men (25.5 ± 4.4 years), assigned in a double-blinded fashion to the hypoxia group (HG) or placebo group (PG), spent 8 h at 5300 m before (PRE) and 2 days after cessation of the IH protocol (POST). Measurements included the evaluation of the Lake Louise Score (LLS) and the HVR. The severity of AMS decreased from PRE to POST in the HG (from 6.0 ± 2.7 at PRE to 4.1 ± 2.1 at POST), whereas the LLS in the PG stayed high (from 5.7 ± 2.9 to 5.5 ± 2.8, respectively). The HVR in the HG increased from 0.73 ± 0.4 L/min/% at PRE to 1.10 ± 0.5 L/min/% at POST and did not increase in the PG. The reduction of the LLS was inversely related to the changes in the HVR (r = -0.434), but the AMS incidence was not different between the HG and the PG at POST. In conclusion, short-term IH reduced the severity of AMS development during a subsequent 8-h exposure to normobaric hypoxia.
间歇性低氧（IH）是一种很有前途的方法，可以诱导适应，从而降低发生急性高原病（AMS）的风险。我们假设，在常压低氧（7×1h 至 4500m）中进行短期 IH 方案可以有效增加低氧通气反应（HVR），并降低 AMS 的发生率和严重程度。因此，26 名男性（25.5±4.4 岁）以双盲方式分配到低氧组（HG）或安慰剂组（PG），在 5300m 处停留 8 小时，然后在 IH 方案停止前（PRE）和 2 天后（POST）进行测量。测量包括评估路易斯湖评分（LLS）和 HVR。在 HG 中，AMS 的严重程度从 PRE 到 POST 降低（从 PRE 的 6.0±2.7 降低到 POST 的 4.1±2.1），而 PG 的 LLS 仍然很高（从 PRE 的 5.7±2.9 降低到 POST 的 5.5±2.8）。HG 的 HVR 从 PRE 的 0.73±0.4 L/min/%增加到 POST 的 1.10±0.5 L/min/%，而 PG 中的 HVR 没有增加。LLS 的降低与 HVR 的变化呈负相关（r=-0.434），但 HG 和 PG 在 POST 时的 AMS 发生率没有差异。总之，短期 IH 可减少随后 8 小时常压低氧暴露期间 AMS 发展的严重程度。
