Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Int J Med Sci. 2023 Sep 18;20(12):1551-1561. doi: 10.7150/ijms.86622. eCollection 2023.
Severe hypoxia can induce a range of systemic disorders; however, surprising resilience can be obtained through sublethal adaptation to hypoxia, a process termed as hypoxic conditioning. A particular form of this strategy, known as intermittent hypoxia conditioning hormesis, alternates exposure to hypoxic and normoxic conditions, facilitating adaptation to reduced oxygen availability. This technique, originally employed in sports and high-altitude medicine, has shown promise in multiple pathologies when applied with calibrated mild to moderate hypoxia and appropriate hypoxic cycles. Recent studies have extensively investigated the protective role of intermittent hypoxia conditioning and its underlying mechanisms using animal models, demonstrating its potential in organ protection. This involves a range of processes such as reduction of oxidative stress, inflammation, and apoptosis, along with enhancement of hypoxic gene expression, among others. Given that intermittent hypoxia conditioning fosters beneficial physiological responses across multiple organs and systems, this review presents a comprehensive analysis of existing studies on intermittent hypoxia and its potential advantages in various organs. It aims to draw attention to the possibility of clinically applying intermittent hypoxia conditioning as a multi-organ protective strategy. This review comprehensively discusses the protective effects of intermittent hypoxia across multiple systems, outlines potential procedures for implementing intermittent hypoxia, and provides a brief overview of the potential protective mechanisms of intermittent hypoxia.
严重的缺氧会引起一系列全身性疾病；然而，通过亚致死适应缺氧（一种称为缺氧适应的过程），可以获得惊人的适应能力。这种策略的一种特殊形式，称为间歇性缺氧适应刺激，交替暴露于缺氧和正常氧条件下，促进对氧气供应减少的适应。这种技术最初应用于运动和高山医学，当应用于校准的轻度至中度缺氧和适当的缺氧循环时，在多种病理学中显示出了希望。最近的研究使用动物模型广泛研究了间歇性缺氧适应的保护作用及其潜在机制，证明了其在器官保护中的潜力。这涉及一系列过程，如减少氧化应激、炎症和细胞凋亡，以及增强缺氧基因表达等。鉴于间歇性缺氧适应促进了多个器官和系统的有益生理反应，本综述全面分析了现有的关于间歇性缺氧及其在各种器官中的潜在优势的研究。本综述旨在提请人们注意将间歇性缺氧适应作为一种多器官保护策略在临床上应用的可能性。本综述全面讨论了间歇性缺氧对多个系统的保护作用，概述了实施间歇性缺氧的潜在程序，并简要概述了间歇性缺氧的潜在保护机制。
