Horwitz C A, Henle W, Henle G, Penn G, Hoffman N, Ward P C
Am J Clin Pathol. 1979 Nov;72(5):807-11. doi: 10.1093/ajcp/72.5.807.
In many laboratories, rapid slide tests incorporating differential absorption have replaced heterophil antibody tube tests in the investigation of suspect infectious mononucleosis. The present report describes serologic data from five individuals whose Monospot tests remained falsely positive for four years or more without other evidence of infectious mononucleosis or underlying disease states. Three of the five had never been infected with the Epstein-Barr virus. All five had negative results when studied with the ox cell hemolysin and the horse cell differential absorption tube tests. False-positive test results have also been encountered in healthy controls, as frequently as in patients with underlying disease states. The authors are unable to attach any clinical significance to the findings of an isolated falsely positive Monospot test even when it persists for many months or years.
在许多实验室中，在对疑似传染性单核细胞增多症的调查中，采用差异吸收的快速玻片试验已取代嗜异性抗体试管试验。本报告描述了五名个体的血清学数据，他们的嗜异性凝集试验持续四年或更长时间呈假阳性，且无其他传染性单核细胞增多症或潜在疾病状态的证据。这五人中三人从未感染过爱泼斯坦-巴尔病毒。用牛红细胞溶血素和马红细胞差异吸收试管试验检测时，这五人的结果均为阴性。在健康对照中也出现过假阳性检测结果，其出现频率与患有潜在疾病状态的患者相同。即使孤立的嗜异性凝集试验假阳性持续数月或数年，作者也无法赋予其任何临床意义。
