Yu M C
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033-0800.
FEMS Microbiol Immunol. 1990 Nov;2(4):235-42. doi: 10.1111/j.1574-6968.1990.tb03524.x.
Nasopharyngeal carcinoma (NPC) is a disease with a remarkable racial and geographical distribution. It is very rare (incidence of less than 1 per 100,000 person-years) in most parts of the world and only a handful of populations are known to deviate from this low-risk profile, which include people of southern China. Eskimos and other natives of the Arctic region, natives of southeast Asia, and mainly Arab populations of north Africa and Kuwait. There is now convincing evidence implicating dietary factors as the primary cause of NPC among Chinese. A series of case-control studies conducted in various Chinese populations with distinct risks of NPC, ranging from the very high-risk Cantonese to the relatively low-risk Northern Chinese, have suggested that ingestion of salted fish and other kinds of preserved foods by the Chinese constitutes the most important cause of NPC development among these people. Preliminary data on Malays in southeast Asia, Eskimos in Alaska, and Arabs of north Africa also suggest that ingestion of preserved foods by these population groups may be responsible for their raised incidence of NPC.
鼻咽癌（NPC）是一种具有显著种族和地理分布特征的疾病。在世界大部分地区，它非常罕见（发病率低于每10万人年1例），只有少数人群偏离这种低风险特征，其中包括中国南方人、爱斯基摩人和北极地区的其他原住民、东南亚原住民，以及主要是北非和科威特的阿拉伯人群体。现在有令人信服的证据表明，饮食因素是中国人患鼻咽癌的主要原因。在中国不同鼻咽癌风险的人群中进行的一系列病例对照研究，从鼻咽癌高风险的广东人到相对低风险的北方中国人，都表明中国人食用咸鱼和其他腌制食品是这些人群中鼻咽癌发生的最重要原因。东南亚马来人、阿拉斯加爱斯基摩人和北非阿拉伯人的初步数据也表明，这些人群食用腌制食品可能是他们鼻咽癌发病率升高的原因。
