Yu M C, Ho J H, Lai S H, Henderson B E
Cancer Res. 1986 Feb;46(2):956-61.
Two hundred fifty incident cases of nasopharyngeal carcinoma under age 35 years in Hong Kong Chinese and an equal number of age- and sex-matched friend controls were interviewed. Mothers of cases and controls were interviewed also, if available, to obtain information on childhood events concerning the study subjects. Consumption of Cantonese-style salted fish during all time periods was significantly associated with nasopharyngeal carcinoma; the association was especially strong during childhood. The relative risk for having Cantonese-style salted fish as one of the first solid foods during weaning was 7.5 (95% confidence limits, 3.9, 14.8), and the relative risk for consuming the food at least once a week compared to less than once a month at age 10 years was 37.7 (95% confidence limits, 14.1, 100.4). It is estimated that over 90% of young nasopharyngeal carcinoma cases in Hong Kong Chinese can be attributed to consumption of this food during childhood.
对香港地区250例35岁以下的鼻咽癌新发病例以及数量相同、年龄和性别匹配的朋友作为对照进行了访谈。如果可能，还对病例和对照的母亲进行了访谈，以获取有关研究对象童年时期事件的信息。各个时间段食用粤式咸鱼均与鼻咽癌显著相关；这种关联在童年时期尤为强烈。断奶期间将粤式咸鱼作为最早的固体食物之一的相对风险为7.5（95%置信区间为3.9至14.8），10岁时每周至少食用一次该食物与每月食用少于一次相比，相对风险为37.7（95%置信区间为14.1至100.4）。据估计，香港地区超过90%的年轻鼻咽癌病例可归因于童年时期食用这种食物。
