Yu M C, Huang T B, Henderson B E
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Int J Cancer. 1989 Jun 15;43(6):1077-82. doi: 10.1002/ijc.2910430621.
We conducted interviews on 306 histologically confirmed incident cases of nasopharyngeal carcinoma (NPC) occurring in residents of Guangzhou City, China, who were under the age of 50 years, and an equal number of age-, sex-, and neighborhood-matched controls. We also interviewed 110 mothers of patients under age 45 years and 139 mothers of controls who were matched to patients under age 45 years, to obtain information on childhood exposures of study subjects. Exposure to salted fish, whether in adulthood or in childhood, was significantly associated with an increased risk of NPC. The association was strongest for exposure during weaning, and exposures at all other periods were no longer related to NPC risk after adjustment for exposure during weaning. Besides salted fish, childhood exposure to 5 other preserved foods (fermented fish sauce, salted shrimp paste, moldy bean curd, and 2 kinds of preserved plum) was significantly related to NPC, and the effects were independent of salted fish exposure. Finally, cases ingested significantly less fresh vegetables and fruits than controls, especially during early childhood, and the differences were not explained by their differing consumption pattern of salted fish and other preserved foods.
我们对中国广州市50岁以下居民中306例经组织学确诊的新发鼻咽癌（NPC）病例以及数量相等的年龄、性别和邻里匹配的对照进行了访谈。我们还访谈了110名45岁以下患者的母亲以及139名与45岁以下患者匹配的对照的母亲，以获取研究对象童年暴露情况的信息。无论在成年期还是童年期，食用咸鱼均与鼻咽癌风险增加显著相关。断奶期暴露的关联最为强烈，在对断奶期暴露进行调整后，其他所有时期的暴露与鼻咽癌风险不再相关。除咸鱼外，童年期暴露于其他5种腌制食品（鱼露、虾酱、腐乳和2种话梅）与鼻咽癌显著相关，且这些影响独立于咸鱼暴露。最后，病例摄入的新鲜蔬菜和水果显著少于对照，尤其是在幼儿期，且这些差异无法通过他们不同的咸鱼和其他腌制食品消费模式来解释。
