Department of Educational Psychology and Instructional Technology, University of Georgia, Athens, GA, USA.
J Autism Dev Disord. 2013 Apr;43(4):817-28. doi: 10.1007/s10803-012-1621-x.
Rates and onset of regression were meta-analyzed from 85 articles representing 29,035 participants with autism spectrum disorders (ASD). Overall prevalence rate for regression was 32.1, 95 % CI [29.5, 34.8] occurring at mean of 1.78 years, 95 % CI [1.67, 1.89]. Regression prevalence rates differed according to four types of regression: language regression, 24.9 %; language/social regression, 38.1 %; mixed regression, 32.5 %; and unspecified regression, 39.1 %. Regression prevalence also differed according to sampling method: population-based prevalence was 21.8 %, clinic-based prevalence was 33.6 %, and parent survey-based prevalence was 40.8 %. Risk of regression was equal for males and females, but higher for individuals diagnosed with autism versus another ASD. Later age of regression onset was predicted by older age of child.
对 85 篇代表 29035 名自闭症谱系障碍（ASD）患者的文章进行了荟萃分析，以评估退行的发生率和发病时间。退行的总体发生率为 32.1%，95%置信区间[29.5,34.8]，平均发病时间为 1.78 岁，95%置信区间[1.67,1.89]。根据四种类型的退行，退行的发生率有所不同：语言退行，24.9%；语言/社交退行，38.1%；混合退行，32.5%；和未指定的退行，39.1%。根据采样方法的不同，退行的发生率也有所不同：基于人群的患病率为 21.8%，基于临床的患病率为 33.6%，基于家长调查的患病率为 40.8%。退行的风险在男性和女性中相等，但在被诊断为自闭症的个体中高于其他 ASD 患者。退行发病时间较晚与儿童年龄较大有关。
