Gu Jian-Jian, He Xin-Hong, Li Wen-Tao, Ji Jun, Peng Wei-Jun, Li Guo-Dong, Wang Sheng-Ping, Xu Li-Chao
Department of Oncology, People's Hospital of Tongzhou District, Nantong City, Jiangsu Province, China.
Acta Radiol. 2012 Oct 1;53(8):862-7. doi: 10.1258/ar.2012.110639. Epub 2012 Aug 1.
Partial splenic artery embolization is an effective treatment for hypersplenism but often lacks long-term benefits.
To evaluate the long-term effects of coil embolization of the splenic artery in patients with liver cirrhosis and hypersplenism.
Forty-nine patients with liver cirrhosis and hypersplenism underwent coil embolization of the main splenic artery. The coils were deployed in the mid- or distal segment of the splenic artery to allow collateral blood flow to the spleen. The following data were collected from 2 weeks to 4 years after the embolization: technical success, length of hospital stay, white blood cell count, platelet count, splenic volume, and complication.
The technical success rate of splenic artery coil embolization was 100%. The post embolization syndrome rate was 75% (36/49) with no incidence of major complications. The mean length of hospital stay was 9 days. After embolization, the patient's white blood and platelet counts increased significantly, peaked at 2 weeks, and gradually decreased during the 4-year follow-up period, but remained at significantly higher levels than pre-embolization levels. Follow-up CT scans demonstrated a gradual increase in the volume of the enhanced portions of the spleens with a decrease in the volume of unenhanced portion. No significant changes occurred in the red blood cell count and liver function after the embolization.
Embolization of the mid-and distal main splenic artery with coils is a safe and effective treatment of hypersplenism in cirrhosis with long-term hematologic benefits.
部分脾动脉栓塞术是治疗脾功能亢进的有效方法，但往往缺乏长期疗效。
评估脾动脉线圈栓塞术对肝硬化合并脾功能亢进患者的长期疗效。
49例肝硬化合并脾功能亢进患者接受了脾动脉主干的线圈栓塞术。线圈被放置在脾动脉的中段或远端，以允许侧支血流供应脾脏。在栓塞术后2周~4年收集以下数据：技术成功率、住院时间、白细胞计数、血小板计数、脾脏体积和并发症。
脾动脉线圈栓塞术的技术成功率为100%。栓塞后综合征发生率为75%（36/49），无严重并发症发生。平均住院时间为9天。栓塞后，患者的白细胞和血小板计数显著增加，在2周时达到峰值，并在4年随访期内逐渐下降，但仍显著高于栓塞前水平。随访CT扫描显示脾脏强化部分的体积逐渐增加，未强化部分的体积减小。栓塞后红细胞计数和肝功能无明显变化。
用线圈栓塞脾动脉主干的中段和远端是治疗肝硬化脾功能亢进的一种安全有效的方法，具有长期血液学益处。
