Case Report: Partial Splenic Artery Embolization for the Treatment of Painful Splenomegaly Secondary to Noncirrhotic Portal Hypertension.

Noncirrhotic portal hypertension (NCPH) is a rare cause of portal hypertension with varied etiologies. We present two cases of painful splenomegaly secondary to NCPH successfully treated with partial splenic artery embolization (PSE). Despite limited literature on PSE's efficacy for NCPH-related painful splenomegaly, our cases demonstrate significant pain relief and reduction in opiate dependence postprocedure. Imaging revealed substantial decreases in spleen size without major complications. PSE emerges as a promising therapeutic option for NCPH-related painful splenomegaly, offering improved quality of life and reduced reliance on analgesics.