Albert So, Oguntayo Oa, Samaila Moa
Ecancermedicalscience. 2012;6:262. doi: 10.3332/ecancer.2012.262. Epub 2012 Jul 23.
This article is a comparative study of two screening methods for pre-invasive lesions of the cervix. The Papanicolaou (Pap) smear, an old and tested screening method, is compared with the findings from visual inspection of the cervix following acetic acid (VIA) wash. VIA is a new screening method being advocated by the World Health Organization as an alternative to Pap smear in low-resource settings.
The objective of this article is to compare the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of VIA and Pap smear.
This was a comparative study carried out in the postnatal clinic of Ahmadu Bello University Teaching Hospital, Zaria. Pap smear samples were taken by the researcher. Samples were fixed in 95% ethyl alcohol and taken to the Pathology Department for interpretation. The cervix was then painted with 3-5% VIA and observed for aceto-white lesions. Suspected areas were biopsied and transported to the Pathology Department for interpretation. Patients with positive Pap smear results were also called back for biopsy. Biopsy served as the reference standard.
There were 351 samples that were suitable for statistical analysis. The sensitivity of VIA was 60%, specificity 94.4%, positive predictive value 50%, negative predictive value 99.4%, and accuracy was 98.6%. Pap smear had a sensitivity of 60%, specificity of 100%, positive predictive value of 100%, negative predictive value of 99.4%, and accuracy of 99.4%.
VIA had a comparable result with Pap smear. It should be incorporated into our national screening programme to complementthe cervical cytology in low-resource settings similar to ours.
本文是对子宫颈癌前病变两种筛查方法的比较研究。巴氏涂片检查是一种古老且经过验证的筛查方法，与醋酸（VIA）冲洗后宫颈视诊的结果进行了比较。VIA是世界卫生组织倡导的一种新的筛查方法，在资源匮乏地区可替代巴氏涂片检查。
本文的目的是比较VIA和巴氏涂片检查的敏感性、特异性、阳性预测值、阴性预测值和准确性。
这是一项在扎里亚阿哈穆杜·贝洛大学教学医院产后诊所进行的比较研究。研究人员采集巴氏涂片样本。样本固定在95%乙醇中，送至病理科进行解读。然后用3-5%的VIA涂抹宫颈，观察醋酸白病变。对可疑区域进行活检，并送至病理科进行解读。巴氏涂片检查结果阳性的患者也被召回进行活检。活检作为参考标准。
有351个样本适合进行统计分析。VIA的敏感性为60%，特异性为94.4%，阳性预测值为50%，阴性预测值为99.4%，准确性为98.6%。巴氏涂片检查的敏感性为60%，特异性为100%，阳性预测值为100%，阴性预测值为99.4%，准确性为99.4%。
VIA与巴氏涂片检查结果相当。应将其纳入我国的筛查计划，以补充与我们类似的资源匮乏地区的宫颈细胞学检查。
