Sun Wei-Hui, Song Ming-Quan, Jiang Chang-Qing, Xin Yong-Ning, Ma Jian-Lin, Liu Ying-Xun, Ma Lei, Lin Zhong-Hua, Li Chang-Yan, Liu Ling, Zhang Mei, Chu Lei-Lei, Jiang Xiang-Jun, Wan Qiang, Zhou Lin, Ren Rong, Meng Ling-Fang
Wei-Hui Sun, Jian-Lin Ma, Ying-Xun Liu, Lei Ma, Qiang Wan, Lin Zhou, Rong Ren, Ling-Fang Meng, Hepatology Department, Qingdao Chengyang People's Hospital, Qingdao 266100, Shandong Province, China.
World J Hepatol. 2012 Jul 27;4(7):224-30. doi: 10.4254/wjh.v4.i7.224.
To evaluate the effect of a 6 and 12 mo lifestyle modification intervention in nonalcoholic fatty liver diseases (NAFLD) in Chengyang District of Qingdao.
Participants with NAFLD who had resided in Chengyang District for more than 5 years were enrolled in this study. After the 6 and 12 mo lifestyle modification intervention based on physical activity, nutrition and behavior therapy, parameters such as body weight, body mass index (BMI), waist circumference, serum alanine aminotransferase (ALT), aspartate aminotransferase values, serum cholesterol, triglycerides, fasting glucose, fasting insulin and visceral fat area (VFA), the liver-spleen ratio and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated and compared between participants with and without the intervention.
Seven hundred and twenty-four participants were assigned to the lifestyle intervention group (LS) and 363 participants were assigned to the control group (CON). After the intervention, body weights in the LS group were significantly decreased compared to those in the CON group at 6 mo (11.59% ± 4.7% vs 0.4% ± 0.2%, P = 0.001) and at 12 mo (12.73% ± 5.6% vs 0.9% ± 0.3%, P = 0.001). Compared with the CON group, BMI was more decreased in the LS group after 6 and 12 mo (P = 0.043 and P = 0.032). Waist circumference was more reduced in the LS group than in CON (P = 0.031 and P = 0.017). After the 6 and 12 mo intervention, ALT decreased significantly in the LS group (P = 0.003 and P = 0.002). After 6 and 12 mo, the metabolic syndrome rate had decreased more in the LS group compared with the CON group (P = 0.026 and P = 0.017). After 12 mo, the HOMA-IR score decreased more obviously in the LS group (P = 0.041); this result also appeared in the VFA after 12 mo in the LS group (P = 0.035).
Lifestyle intervention was effective in improving NAFLD in both 6 and 12 mo interventions. This intervention offered a practical approach for treating a large number of NAFLD patients in the Chengyang District of Qingdao.
评估在青岛市城阳区对非酒精性脂肪性肝病（NAFLD）患者进行6个月和12个月生活方式改变干预的效果。
纳入在城阳区居住超过5年的NAFLD患者。基于体育活动、营养和行为疗法进行6个月和12个月的生活方式改变干预后，对干预组和非干预组患者的体重、体重指数（BMI）、腰围、血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶值、血清胆固醇、甘油三酯、空腹血糖、空腹胰岛素和内脏脂肪面积（VFA）、肝脾比以及胰岛素抵抗稳态模型评估（HOMA-IR）等参数进行评估和比较。
724名参与者被分配到生活方式干预组（LS），363名参与者被分配到对照组（CON）。干预后，LS组在6个月时（11.59%±4.7% vs 0.4%±0.2%，P = 0.001）和12个月时（12.73%±5.6% vs 0.9%±0.3%，P = 0.001）的体重相较于CON组显著下降。与CON组相比，LS组在6个月和12个月后的BMI下降更明显（P = 0.043和P = 0.032）。LS组的腰围比CON组减少更多（P = 0.031和P = 0.017）。在6个月和12个月干预后，LS组的ALT显著下降（P = 0.003和P = 0.002）。在6个月和12个月后，LS组的代谢综合征发生率相较于CON组下降更多（P = 0.026和P = 0.017）。12个月后，LS组的HOMA-IR评分下降更明显（P = 0.041）；12个月后LS组的VFA也出现了同样的结果（P = 0.035）。
生活方式干预在6个月和12个月的干预中对改善NAFLD均有效。该干预为青岛市城阳区大量NAFLD患者提供了一种切实可行的治疗方法。
