Siomek Agnieszka
Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Department of Clinical Biochemistry, Poland.
Acta Biochim Pol. 2012;59(3):323-31. Epub 2012 Aug 1.
The activation of NF-κB transcription factor is critical for a wide range of processes such as immunity, inflammation, cell development, growth and survival. It is activated by a variety of stimuli including cytokines, ionizing radiation and oxidative stress. Redox modulations of NF-κB pathway have been widely demonstrated. Studies carried out during last years have advanced our knowledge about possible connections between NF-κB pathway and the impact of free radicals. This review is an endeavor to gather recent results focused on this issue, although an important question, whether oxidative stress plays a physiological role in NF-κB activation, seems to be still unanswered.
核因子-κB（NF-κB）转录因子的激活对于免疫、炎症、细胞发育、生长和存活等广泛过程至关重要。它可被多种刺激激活，包括细胞因子、电离辐射和氧化应激。NF-κB信号通路的氧化还原调节已得到广泛证实。过去几年进行的研究增进了我们对NF-κB信号通路与自由基影响之间可能联系的认识。尽管氧化应激在NF-κB激活中是否发挥生理作用这一重要问题似乎仍未得到解答，但本综述旨在收集关于该问题的最新研究结果。
