Research Group on Adolescent Health, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital Lausanne, Switzerland.
Nicotine Tob Res. 2013 Feb;15(2):557-61. doi: 10.1093/ntr/nts138. Epub 2012 Aug 1.
This study examines the relationship between nicotine exposure and tobacco addiction among young smokers consuming either only tobacco or only tobacco and cannabis.
Data on tobacco and cannabis use were collected by a questionnaire among 313 adolescents and young adults in Western Switzerland between 2009 and 2010. In addition, a urine sample was used to determine urinary cotinine level. Nicotine addiction was measured using the Fagerström Test for Nicotine Dependence (FTND). In this study, we focused on a sample of 142 participants (mean age 19.54) that reported either smoking only tobacco cigarettes (CIG group, n = 70) or smoking both tobacco cigarettes and cannabis (CCS group, n = 72).
The FTND did not differ significantly between CIG (1.96 ± 0.26) and CCS (2.66 ± 0.26) groups (p = 0.07). However, participants in the CCS group smoked more cigarettes (8.30 ± 0.79 vs. 5.78 ± 0.8, p = 0.03) and had a higher mean cotinine value (671.18 ± 67.6 vs. 404.32 ± 68.63, p = 0.008) than the CIG group. Further, the association between cotinine and FTND was much stronger among the CIG than among the CCS group (regression coefficient of 0.0031 vs. 0.00099, p < 0.0001).
Adolescents smoking tobacco and cannabis cigarettes featured higher levels of cotinine than youth smoking only tobacco; however, there was no significant difference in the addiction score. The FTND score is intended to measure nicotine dependence from smoked tobacco cigarettes. Hence, to accurately determine nicotine exposure and the associated dependence among young smokers, it seems necessary to inquire about cannabis consumption.
本研究考察了仅吸食烟草或同时吸食烟草和大麻的青少年吸烟者中尼古丁暴露与烟草成瘾之间的关系。
2009 年至 2010 年期间,在瑞士西部的 313 名青少年和年轻人中通过问卷收集了烟草和大麻使用数据。此外,还使用尿液样本来确定尿中可替宁水平。尼古丁成瘾使用尼古丁依赖 Fagerström 测试(FTND)进行测量。在这项研究中,我们关注的是报告仅吸食香烟(CIG 组,n = 70)或同时吸食香烟和大麻(CCS 组,n = 72)的 142 名参与者的样本。
CIG(1.96 ± 0.26)和 CCS(2.66 ± 0.26)组之间的 FTND 没有显著差异(p = 0.07)。然而,CCS 组的参与者吸烟更多(8.30 ± 0.79 比 5.78 ± 0.8,p = 0.03),尿中可替宁值更高(671.18 ± 67.6 比 404.32 ± 68.63,p = 0.008)比 CIG 组。此外,在 CIG 组中,可替宁与 FTND 之间的关联强于 CCS 组(回归系数为 0.0031 比 0.00099,p < 0.0001)。
吸食烟草和大麻香烟的青少年尿中可替宁水平高于仅吸食烟草的青少年;然而,成瘾评分没有显著差异。FTND 评分旨在衡量来自吸食的烟草香烟的尼古丁依赖。因此,为了准确确定年轻吸烟者的尼古丁暴露和相关依赖,似乎有必要询问大麻的使用情况。