Smith D A, Trope G E
Department of Ophthalmology, Toronto General Hospital, Ontario, Canada.
Br J Ophthalmol. 1990 Oct;74(10):605-6. doi: 10.1136/bjo.74.10.605.
The intraocular pressures (IOP) were measured in both eyes of 25 healthy volunteers in various body positions. One eye was pretreated with levobunolol 0.5% or placebo applied in a masked, randomised fashion, while the other served as control. IOP changes in response to levobunolol and to changes in position were significant (p less than 0.0001). However, pressure rises relative to position were not significantly different in eyes treated with drug vs placebo. Levobunolol did not alter relative changes in IOP from changes in body position. However, the overall lowering effect may offer some protection to patients with glaucoma.
在25名健康志愿者的双眼处于不同体位时测量眼内压（IOP）。一只眼睛预先以盲法、随机方式应用0.5%的左布诺洛尔或安慰剂，另一只眼睛作为对照。左布诺洛尔和体位变化引起的IOP变化具有显著性（p<0.0001）。然而，用药眼与安慰剂眼相比，相对于体位的眼压升高并无显著差异。左布诺洛尔并未改变因体位变化而引起的IOP相对变化。不过，其总体降低眼压的作用可能会为青光眼患者提供一定的保护。
