Krieglstein G K, Novack G D, Voepel E, Schwarzbach G, Lange U, Schunck K P, Lue J C, Glavinos E P
Br J Ophthalmol. 1987 Apr;71(4):250-3. doi: 10.1136/bjo.71.4.250.
Topical levobunolol 0.5% was compared with topical metipranolol 0.6% for efficacy, safety, and comfort in 46 patients with open angle glaucoma or ocular hypertension. The study was of parallel design, randomised, double-masked, and of three months' duration. After a washout interval the study medications were instilled twice daily in both eyes. The overall mean decrease in intraocular pressure (IOP) was approximately 7 mmHg in both groups. More than 90% of patients in both groups successfully completed the study. Both agents caused slight decreases in heart rate and blood pressure. More complaints of burning and stinging were reported in the metipranolol group than in the levobunolol group. This three-month, 46-patient study showed levobunolol 0.5% and metipranolol 0.6% to be similarly effective ocular hypotensive agents.
在46例开角型青光眼或高眼压症患者中，对0.5%的噻吗洛尔滴眼液与0.6%的美替洛尔滴眼液的疗效、安全性及舒适度进行了比较。该研究采用平行设计、随机、双盲，为期3个月。经过洗脱期后，研究药物每天双眼各滴入两次。两组的眼内压（IOP）总体平均下降约7 mmHg。两组均有超过90%的患者成功完成了研究。两种药物均导致心率和血压略有下降。美替洛尔组报告的烧灼感和刺痛感比噻吗洛尔组更多。这项为期3个月、涉及46名患者的研究表明，0.5%的噻吗洛尔和0.6%的美替洛尔是同样有效的降眼压药物。
