系统生物学：未来的个性化医疗？
Systems biology: personalized medicine for the future?
机构信息
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.
出版信息
Curr Opin Pharmacol. 2012 Oct;12(5):623-8. doi: 10.1016/j.coph.2012.07.011. Epub 2012 Jul 31.
Abstract
Systems biology is actively transforming the field of modern health care from symptom-based disease diagnosis and treatment to precision medicine in which patients are treated based on their individual characteristics. Development of high-throughput technologies such as high-throughout sequencing and mass spectrometry has enabled scientists and clinicians to examine genomes, transcriptomes, proteomes, metabolomes, and other omics information in unprecedented detail. The combined 'omics' information leads to a global profiling of health and disease, and provides new approaches for personalized health monitoring and preventative medicine. In this article, we review the efforts of systems biology in personalized medicine in the past 2 years, and discuss in detail achievements and concerns, as well as highlights and hurdles for future personalized health care.
摘要
系统生物学正在将现代医疗保健领域从基于症状的疾病诊断和治疗转变为基于个体特征的精准医疗。高通量技术（如高通量测序和质谱技术）的发展使科学家和临床医生能够以前所未有的细节研究基因组、转录组、蛋白质组、代谢组和其他组学信息。综合的‘组学’信息导致对健康和疾病的全面分析，并为个性化健康监测和预防医学提供了新的方法。在本文中，我们回顾了过去 2 年系统生物学在个性化医学中的努力，并详细讨论了成就和关注点，以及未来个性化医疗保健的亮点和障碍。
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