Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
J Appl Oral Sci. 2012 May-Jun;20(3):318-22. doi: 10.1590/s1678-77572012000300004.
Iron has been suggested to reduce the erosive potential of cola drinks in vitro.
The aim of this study was to evaluate in situ the effect of ferrous sulfate supplementation on the inhibition of the erosion caused by a cola drink.
Ten adult volunteers participated in a crossover protocol conducted in two phases of 5 days, separated by a washout period of 7 days. In each phase, they wore palatal devices containing two human enamel and two human dentin blocks. The volunteers immersed the devices for 5 min in 150 mL of cola drink (Coca-ColaTM, pH 2.6), containing ferrous sulfate (10 mmol/L) or not (control), 4 times per day. The effect of ferrous sulfate on the inhibition of erosion was evaluated by profilometry (wear). Data were analyzed by paired t tests (p<0.05).
The mean wear (±se) was significantly reduced in the presence of ferrous sulfate, both for enamel (control: 5.8±1.0 µm; ferrous sulfate: 2.8±0.6 µm) and dentin (control: 4.8±0.8 µm; ferrous sulfate: 1.7±0.7 µm).
The supplementation of cola drinks with ferrous sulfate can be a good alternative for the reduction of their erosive potential. Additional studies should be done to test if lower ferrous sulfate concentrations can also have a protective effect as well as the combination of ferrous sulfate with other ions.
铁已被认为可降低可乐饮料的体外侵蚀性。
本研究旨在体内评估硫酸亚铁补充对可乐饮料引起的侵蚀抑制作用。
10 名成年志愿者参与了一项交叉试验，分为两个阶段，每个阶段持续 5 天，洗脱期为 7 天。在每个阶段，志愿者佩戴含有两个人牙釉质和两个人牙本质块的腭部装置。志愿者每天将装置浸入 150ml 可乐（可口可乐 TM ，pH2.6）中 5 分钟，含有或不含有硫酸亚铁（10mmol/L）。通过轮廓仪（磨损）评估硫酸亚铁对抑制侵蚀的作用。采用配对 t 检验进行数据分析（p<0.05）。
硫酸亚铁存在时，牙釉质（对照组：5.8±1.0 µm；硫酸亚铁组：2.8±0.6 µm）和牙本质（对照组：4.8±0.8 µm；硫酸亚铁组：1.7±0.7 µm）的平均磨损明显减少。
可乐饮料中添加硫酸亚铁可能是降低其侵蚀性的一种有效方法。应进行更多研究以测试较低浓度的硫酸亚铁是否也具有保护作用，以及硫酸亚铁与其他离子的联合作用。
