Chen Taowu, Chen Yulin, Wang Heng, Li Xueqing, Guo Xin, Tan Hong, Zhang Xiaoyan, Li Chunhui, Shi Rui, Sun Chen
Department of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, Sichuan, China.
School of Stomatology, Southwest Medical University, Luzhou, Sichuan, China.
BMC Oral Health. 2025 Mar 19;25(1):405. doi: 10.1186/s12903-025-05763-3.
Dental caries is a localized deterioration of hard tissues caused by acidic by-products of bacterial fermentation of dietary carbohydrates. However, except for fluoride, there were few studies focusing on the direct association between other trace elements. This study aimed to explore how other trace elements affect dental caries.
Data from 10,426 individuals were collected from the National Health and Nutrition Examination Survey (NHANES) during the 2010-2016 cycle. The sample was restricted to individuals aged 20 years or older who had complete clinical oral examination data, and who had also completed blood (N = 10,086), serum (N = 5,152), or urine tests (N = 5,297). These three groups were weighted to represent multi-year data. The effects of 20 trace elements on dental caries experience were investigated using quartiles of continuous variables and weighted multivariate logistic regression models.
The analysis revealed significant differences in trace elements (lead, cadmium, mercury, molybdenum, tin, and tungsten) between individuals with no dental caries experience and those with dental caries experience (P < 0.05). Adjusted results from the weighted multivariate logistic regression model showed that the odds ratios (OR) for following trace elements were significantly positively associated with dental caries experience: lead (OR = 1.0105; 95% CI 1.0030-1.0181; P = 0.0077), cobalt (OR = 1.0048; 95% CI 1.001-1.0087; P = 0.0154), cesium (OR = 1.0028; 95% CI 1.0011-1.0046; P = 0.0027), and arsenic (OR = 1.0002; 95% CI 1-1.0004; P = 0.0244), while iron (OR = 0.9974; 95% CI 0.9954-0.9994; P = 0.0116) showed the negative association.
The results of this cross-sectional study conducted on the U.S. population identified a statistically significant positive association between dental caries and trace elements, including lead, cobalt, cesium, and arsenic, while a negative association was observed with iron.
龋齿是由膳食碳水化合物细菌发酵产生的酸性副产物引起的硬组织局部恶化。然而，除氟以外，很少有研究关注其他微量元素之间的直接关联。本研究旨在探讨其他微量元素如何影响龋齿。
从2010 - 2016年周期的美国国家健康与营养检查调查（NHANES）中收集了10426名个体的数据。样本仅限于年龄在20岁及以上、有完整临床口腔检查数据且还完成了血液（N = 10086）、血清（N = 5152）或尿液检测（N = 5297）的个体。对这三组数据进行加权以代表多年数据。使用连续变量的四分位数和加权多变量逻辑回归模型研究20种微量元素对龋齿经历的影响。
分析显示，无龋齿经历者和有龋齿经历者之间的微量元素（铅、镉、汞、钼、锡和钨）存在显著差异（P < 0.05）。加权多变量逻辑回归模型的校正结果表明，以下微量元素的比值比（OR）与龋齿经历显著正相关：铅（OR = 1.0105；95% CI 1.0030 - 1.0181；P = 0.0077）、钴（OR = 1.0048；95% CI 1.001 - 1.0087；P = 0.0154）、铯（OR = 1.0028；95% CI 1.0011 - 1.0046；P = 0.0027）和砷（OR = 1.0002；95% CI 1 - 1.0004；P = 0.0244），而铁（OR = 0.9974；95% CI 0.9954 - 0.9994；P = 0.0116）显示出负相关。
这项针对美国人群的横断面研究结果表明，龋齿与包括铅、钴、铯和砷在内的微量元素之间存在统计学上显著的正相关，而与铁存在负相关。
