Department of Pulmonary and Critical Care, Yuzuncu Yil University Medical Faculty, Turkey.
Int J Med Sci. 2012;9(6):406-12. doi: 10.7150/ijms.4715. Epub 2012 Jul 21.
Pulmonary hypertension (PH) is a common and well established complication of chronic obstructive pulmonary disease (COPD). Its presence is associated with decreased survival. This study was designed to investigate the PH frequency and its relations in hospitalized tobacco and biomass related COPD patients.
The study was a retrospective review of inpatients with COPD defined as a history of tobacco or biomass smoking, Pulmonary function tests (PFT) within stable status, an echocardiogram within stable status. PH was defined as systolic pulmonary artery pressure (sPAP) >35 mmHg. Of the 694 individuals, 600 had suitable aspects for inclusion of study. All Females were biomass exposer and males were tobacco smoker. The Prevalence of PH was found more frequent in females than males. It was more prominent in moderate level COPD cases (56,2% and 37,5%, P<0,002). Both groups had airflow limitation, hypercapnia and hypoxemia, but no differences were found in terms of PaCO(2) and PaO2. However, FEV1 % was lower in males than females (p<0,005). On the other hand, FVC % was lower in the females compared with the males (p < 0.02). When analyzing the influence of PFT and demographic parameters on PH in separate COPD level groups, the results a bit varied among the groups.
Our study demonstrated that PH frequency is higher in female COPD cases due to biomass smoke than in male COPD cases due to tobacco smoke. The influence of FVC % on the risk of a person having PH increased with increasing COPD level.
肺动脉高压（PH）是慢性阻塞性肺疾病（COPD）的常见且已确立的并发症。其存在与生存率降低有关。本研究旨在调查住院的与烟草和生物量相关的 COPD 患者中 PH 的频率及其关系。
该研究回顾性分析了 COPD 住院患者，定义为有吸烟史（包括烟草或生物量）、稳定期内的肺功能测试（PFT）和稳定期内的超声心动图。PH 定义为收缩压肺动脉压（sPAP）>35mmHg。在 694 名个体中，有 600 名具有适合纳入研究的方面。所有女性都是生物量暴露者，男性都是烟草吸烟者。PH 的患病率在女性中比男性更常见。在中度 COPD 病例中更为突出（56.2%和 37.5%，P<0.002）。两组均存在气流受限、高碳酸血症和低氧血症，但在 PaCO2 和 PaO2 方面没有差异。然而，男性的 FEV1%低于女性（p<0.005）。另一方面，女性的 FVC%低于男性（p<0.02）。在分别分析 COPD 不同水平组中 PFT 和人口统计学参数对 PH 的影响时，结果在各组之间略有不同。
我们的研究表明，由于生物量烟雾，女性 COPD 病例中 PH 的频率高于男性 COPD 病例中由于烟草烟雾引起的 PH。FVC%对个体发生 PH 的风险的影响随着 COPD 水平的增加而增加。
