Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate School of Medicine, Singapore, Singapore.
PLoS One. 2012;7(7):e38469. doi: 10.1371/journal.pone.0038469. Epub 2012 Jul 30.
In this study of the effect of bipolar status and presence of BDNF Val66Met polymorphism on differences in regional brain volumes, we hypothesized based on previous studies that 1) bipolar subjects will have smaller regional brain volumes than healthy controls; 2) BDNF Met66 allele carriers within the same population are likely to have smaller regional brain volumes as compared to Val66 homozygyotes. In our Caucasian sample of 166 bipolar subjects and 64 gender-matched healthy controls, we found significant decreases in total (p = 0.005) and regional gray matter volumes in bipolar patients compared to healthy controls, more pronounced in the inferior and posterior parts of the brain, together with a concomitant increase in total CSF (p = 0.012) particularly in the lateral ventricles (p = 0.023). However, there was no difference in white matter volumes noted by other studies. Furthermore we did not find significant differences in other brain regions that have been reported by other authors. Nor did we find a significant effect of BDNF on these measurements.
在这项关于双相状态和 BDNF Val66Met 多态性对脑区体积差异影响的研究中，我们基于以往的研究提出假设：1）双相患者的脑区体积小于健康对照组；2）在同一人群中，BDNF Met66 等位基因携带者的脑区体积小于 Val66 纯合子。在我们的 166 名白种人双相患者和 64 名性别匹配的健康对照组的样本中，我们发现与健康对照组相比，双相患者的全脑（p = 0.005）和灰质体积显著减少，这种减少在大脑的下部和后部更为明显，同时总脑脊液（p = 0.012）增加，特别是侧脑室（p = 0.023）。然而，其他研究并未发现白质体积的差异。此外，我们没有发现其他作者报告的其他脑区有显著差异。BDNF 对这些测量值也没有显著影响。
