State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Org Lett. 2012 Aug 17;14(16):4142-5. doi: 10.1021/ol301785x. Epub 2012 Aug 3.
We herein report comparative analysis of two versions of the biosynthetic gene clusters of antimycins, a natural product family possessing up to 44 distinct entities. The biosynthetic pathway of antimycins is amenable to the high structural variation of the substrates, supported by successes in heterologous expression of the ant cluster and in fluorine incorporation. The latter facilitated the investigation of the structure-activity relationship into the usually invariable 3-formamidosalicylic acid moiety of the molecules.
我们在此报告了两种抗霉素生物合成基因簇的比较分析，抗霉素是一个拥有多达 44 种不同实体的天然产物家族。抗霉素的生物合成途径适合于底物的高结构变化，这得到了异源表达抗霉素簇和氟原子掺入的成功支持。后者促进了对分子中通常不变的 3-甲酰胺水杨酸部分的结构-活性关系的研究。
