Rejeski W J, Gregg E, Kaplan J R, Manuck S B
Department of Health and Sport Science Wake Forest University, Winston-Salem, NC 27109.
Health Psychol. 1990;9(6):774-91. doi: 10.1037//0278-6133.9.6.774.
Examined the effects of anabolic-androgenic steroids (AS) on behavior, baseline heart rate (HR), and stress-induced HR responses. Twenty-four cynomolgus monkeys were assigned to four mixed social groups of both AS and sham control animals. For 2 months, AS-treated monkeys received biweekly injections of testosterone, and, on an identical schedule, the control animals were injected with a sham solution. Behavioral data revealed that AS disrupted the social milieu such that all dominant animals exhibited increases in dominant behavior and subordinates manifested increased submission. These changes returned to pretest levels 8 weeks following termination of the drug intervention. Affiliative behaviors decreased on the part of all animals as a function of AS and, with the exception of play behavior, failed to return to pretest levels after the 8-week period of recovery. AS created an increase in baseline HR, particularly among the dominant animals. Interestingly, the subordinate AS animals experienced a decrease in baseline HR response. AS had no apparent influence on stress-induced HR reactivity.
研究了合成代谢雄激素类固醇（AS）对行为、基础心率（HR）以及应激诱导的心率反应的影响。将24只食蟹猴分为四个混合社会群体，既有接受AS处理的动物，也有假手术对照组动物。在2个月的时间里，接受AS处理的猴子每两周注射一次睾酮，按照相同的时间表，对照组动物注射假溶液。行为数据显示，AS扰乱了社会环境，所有占主导地位的动物表现出主导行为增加，从属动物表现出顺从增加。在药物干预终止8周后，这些变化恢复到测试前水平。所有动物的亲和行为都因AS而减少，并且除了玩耍行为外，在8周的恢复期后未能恢复到测试前水平。AS使基础心率增加，特别是在占主导地位的动物中。有趣的是，从属的AS处理动物的基础心率反应有所下降。AS对应激诱导的心率反应性没有明显影响。
