Rejeski W J, Brubaker P H, Herb R A, Kaplan J R, Koritnik D
Department of Cardiac Rehabilitation, Wake Forest University, Winston-Salem, North Carolina 27109.
J Behav Med. 1988 Feb;11(1):95-105. doi: 10.1007/BF00846172.
An animal model was employed to examine the effect of testosterone on aggressive behavior patterns. Ten cynomolgus monkeys were assigned to either an experimental or a control group and given biweekly injections; the experimental group received testosterone propionate, and the controls a sham solution. Prior to and upon the completion of an 8-week treatment period, behavioral observations were conducted. Although the administration of testosterone resulted in a significant increase in aggression, more important was the finding that changes in behavior were mediated by social status; that is, the incidence of both contact and noncontact aggression in dominant monkeys was far greater than the frequency of these behaviors in subordinate monkeys. These data are discussed in terms of the potential role of anabolic steroids as a risk factor in cardiovascular disease.
采用动物模型来研究睾酮对攻击行为模式的影响。将十只食蟹猴分为实验组和对照组，每两周注射一次；实验组接受丙酸睾酮注射，对照组接受假溶液注射。在为期8周的治疗期开始前及结束时，进行行为观察。尽管睾酮给药导致攻击性显著增加，但更重要的发现是行为变化是由社会地位介导的；也就是说，优势猴中接触性和非接触性攻击的发生率远高于从属猴中这些行为的频率。根据合成代谢类固醇作为心血管疾病风险因素的潜在作用对这些数据进行了讨论。
