Departamento de Cabeza y Cuello, Instituto Nacional de Cancerología, Mexico City, Mexico.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Sep;114(3):350-7. doi: 10.1016/j.oooo.2012.05.003.
The aim of this study was to determine the frequency and genotype distribution of single and multiple human papillomavirus (HPV) infections in head and neck squamous cell carcinomas (HNSCCs) in a Mexican population and to assess their associations with smoking and drinking habits and clinicopathologic characteristics.
A cross-sectional study was performed on a sample of patients diagnosed with HNSCCs. Tumor DNA was amplified using polymerase chain reaction with HPV consensus and multiplex primers. The associations among HPV status, survival, and clinical characteristics were analyzed.
Sixteen of the 43 HNSCCs were HPV positive. HPV16 was the most prevalent type, with single infections present in 5 cases, whereas another 5 cases were combined with HPV56 infection. There was a significant association between HPV infection and oropharyngeal cancers. HPV positivity was associated with overall survival at a nearly significant P level of 0.06.
Our data support the importance of HPV infection in oropharyngeal cancer, with a trend toward higher survival in HPV-positive cases.
本研究旨在确定 HPV 感染在墨西哥人群头颈部鳞状细胞癌中的频率和基因型分布，以及评估 HPV 感染与吸烟和饮酒习惯及临床病理特征之间的关系。
对诊断为头颈部鳞状细胞癌的患者样本进行了一项横断面研究。使用 HPV 通用和多重引物的聚合酶链反应扩增肿瘤 DNA。分析 HPV 状态、生存和临床特征之间的关系。
43 例 HNSCC 中有 16 例 HPV 阳性。HPV16 是最常见的类型，5 例为单一感染，另有 5 例与 HPV56 感染合并。HPV 感染与口咽癌显著相关。HPV 阳性与总生存率有显著相关性（P=0.06）。
我们的数据支持 HPV 感染在口咽癌中的重要性，HPV 阳性病例的生存率有升高趋势。
