Department of Cell, Developmental, and Integrative Biology, University of Alabama, 1918 University Boulevard, Birmingham, AL, 35294-0005, USA.
Allergy Asthma Clin Immunol. 2012 Aug 3;8(1):13. doi: 10.1186/1710-1492-8-13.
Aerobic exercise appears to have clinical benefits for many asthmatics, yet a complete understanding of the mechanisms underlying these benefits has not been elucidated at this time.
The objective of this study was to determine feasibility for a larger, future study that will define the effect of aerobic exercise on cellular, molecular, and functional measures in adults with mild-moderate asthma.
Recruited subjects were randomized into usual care (sedentary) or usual care with moderate intensity aerobic exercise treatment groups.
SETTING / PARTICIPANTS: Nineteen adults with mild-moderate asthma but without a recent history of exercise were recruited at the UAB Lung Health Center, Birmingham, AL.
The exercise group underwent a 12 week walking program exercising at 60 - 75% of maximum heart rate (HRmax). Subjects self-monitored HRmax levels using heart rate monitors; exercise diaries and recreation center sign-in logs were also used.
Functional measures, including lung function and asthma control scores, were evaluated for all subjects at pre- and post-study time-points; fitness measures were also assessed for subjects in the exercise group. Peripheral blood and nasal lavage fluid were collected from all subjects at pre- and post-study visits in order to evaluate cellular and molecular measures, including cell differentials and eosinophilic cationic protein (ECP).
Sixteen subjects completed the prescribed protocol. Results show that subjects randomized to the exercise group adhered well (80%) to the exercise prescription and exhibited a trend toward improved fitness levels upon study completion. Both groups exhibited improvements in ACQ scores. No changes were observed in lung function (FEV1, FEV1/FVC), cell differentials, or ECP between groups.
Results indicate that a moderate intensity aerobic exercise training program may improve asthma control and fitness levels without causing asthma deterioration in adult asthmatics. As such, these findings demonstrate the feasibility of the study protocol in preparation for a larger, clinical trial that will elucidate the functional consequences of aerobic exercise on asthmatic cellular and molecular responses.
有氧运动似乎对许多哮喘患者具有临床益处，但目前尚未完全阐明这些益处的机制。
本研究旨在确定一项更大的未来研究的可行性，该研究将定义有氧运动对轻度至中度哮喘成人的细胞、分子和功能测量的影响。
招募的受试者被随机分为常规护理（久坐）或常规护理加中等强度有氧运动治疗组。
地点/参与者：19 名轻度至中度哮喘但近期无运动史的成年人在阿拉巴马州伯明翰的 UAB 肺健康中心招募。
运动组进行了 12 周的步行计划，运动强度为最大心率（HRmax）的 60-75%。受试者使用心率监测器自我监测 HRmax 水平；还使用了运动日记和娱乐中心签到日志。
所有受试者在研究前后的时间点评估功能测量，包括肺功能和哮喘控制评分；还评估了运动组受试者的健康测量。所有受试者在研究前后的访问中采集外周血和鼻洗液，以评估细胞和分子测量，包括细胞差异和嗜酸性阳离子蛋白（ECP）。
16 名受试者完成了规定的方案。结果表明，随机分配到运动组的受试者很好地遵守了（80%）运动处方，并在研究结束时表现出健康水平提高的趋势。两组的 ACQ 评分均有所改善。两组之间的肺功能（FEV1、FEV1/FVC）、细胞差异或 ECP 均无变化。
结果表明，中等强度的有氧运动训练方案可改善哮喘控制和健康水平，而不会导致成年哮喘患者的哮喘恶化。因此，这些发现表明该研究方案具有可行性，可进行更大规模的临床试验，以阐明有氧运动对哮喘患者细胞和分子反应的功能影响。
